hsa-mir-3176: Hsa-mir-3176 is one of the top 10 most upregulated miRNAs identified in a network analysis, targeting 1,479 genes [PMC8327780]. It is significantly downregulated in basal cell carcinomas (BCCs) and regulates the smoothened homolog precursor (SMO), an oncogene [PMC8357504]. Hsa-mir-3176 is a TE-derived miRNA and its TE sequence is only present inside precursors when submitted with the extended sequence in CENSOR [PMC3495686]. It is one of the miRNAs that are regulated by ESR2, targeting 61 miRNAs [PMC8074411]. Hsa-mir-3176, along with hsa-miR-2278 and hsa-miR-3654, shows a statistically significant correlation with patients' overall survival (OS) [PMC8799182]. These three miRNAs are also identified as important cores of the ceRNET network [PMC8799182]. References: [PMC8327780] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8327780/ [PMC8357504] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357504/ [PMC3495686] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495686/ [PMC8074411] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074411/ [PMC8799182] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8799182/