hsa-mir-4763: Hsa-mir-4763 is a microRNA that may play a role in the aggressiveness of papillary thyroid microcarcinoma (PTMC) by regulating the expression of sarcoma gene (SRC) [PMC9281586]. In a study analyzing PTMC samples, the expression levels of hsa-mir-4763, hsa-miR-6775, and circRNA-000121 were compared between PTMC patients with and without lymph node metastasis [PMC9281586]. The study found that the expression of hsa-mir-4763 was reduced in PTMC, suggesting its involvement in PTMC aggressiveness [PMC9281586]. However, binary logistic regression analysis did not show a significant association between the expression levels of circRNA-000121, hsa-miR-6775, hsa-mir-4763, SRC, and matrix metalloproteinase 14 (MMP-14) with lymph node metastasis in PTMC tissues [PMC9281586]. Additionally, the levels of circRNA-000121 and circRNA-004183 in peripheral blood were not associated with lymph node metastasis [PMC9281586]. The study also suggested that circRNA-000121 may upregulate SRC expression by binding to hsa-mir-4763 and enhance PTMC aggressiveness leading to lymph node metastasis [PMC9281586]. However, it is worth noting that there is no clear evidence for the expression of annotated hsa-mir-4763 in brain samples or ENCODE cell lines. Furthermore, no expression was found for its orthologs in Macaca mulatta brain or domestic dog lymphocytes [PMC3384580]. Additionally, it was found that bta-mir2443 is not an orthologous sequence to hsa-mir4763 [PMC3384580].