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Homo sapiens (human) LIFR antisense RNA 1 (LIFR-AS1) URS0000490DBB_9606

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LIFR-AS1: LncRNA LIFR-AS1, also known as leukemia inhibitory factor receptor antisense RNA 1, has been studied in various types of cancer. Overexpression of LIFR-AS1 has been found to promote proliferation and invasion of osteosarcoma cells [PMC8017664]. In contrast, LIFR-AS1 expression is significantly lower in non-small cell lung cancer (NSCLC) tissues compared to normal tissues [PMC8392855]. The potential molecular mechanisms by which LIFR-AS1 promotes breast cancer cell proliferation, migration, and invasion have been investigated through bioinformatics analyses and mechanistic investigations [PMC6614576]. Additionally, LIFR-AS1 has been implicated in tumorigenesis [PMC8017664]. In colorectal cancer (CRC) cells, knockdown of LIFR-AS1 reduced the effect of photodynamic therapy on proliferation and apoptosis, suggesting a potential tumor suppressor role through interaction with miR-29a [PMC9624034]. Furthermore, miR-197-3p has been identified as a candidate target of LIFR-AS1 in breast cancer cells [PMC6614576]. In NSCLC, the anti-invasive activity of LIFR-AS1 is attributed to its ability to sponge miR-942-5p [PMC7245777]. In summary, lncRNA LIFR-AS1 plays diverse roles in different types of cancer. It can promote proliferation and invasion in osteosarcoma cells but exhibits lower expression levels in NSCLC tissues. The molecular mechanisms underlying its effects on breast cancer cell behavior have been investigated. Additionally, it may act as a tumor suppressor by interacting with miRNAs such as miR29a and miRNA9425p. These findings highlight the importance of understanding the role of lncRNAs like LIFR-AS1 in cancer progression and provide potential targets for therapeutic interventions.

Targeting miRNAs 1 total

According to LncBase, this RNA is targeted by the following miRNAs:

Genome locations

Gene Ontology annotations

Sequence

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GCGCGCGGGUGCUCCAAGGAGUCGGAGGAACGCGGCCGCGCGACGGGCCCCGGACGCCGAGGGUGGUGCUUCCUCCGAGCCUCCGGUGGUGAGGCCGCUCUCAGAAGGUCAUGGAAGCGCAGGGGAGAGCGAGGCGGCCGAGCCCAGGCAAAUCCUCGAGAAAGGCCGAGUGCGCGACGGCUCUGCGGGGAGGACCGCGCCUCCCCGAAUGCGGCCGCUGCUGCCGCUGCAAACAGUGCCUUGAGGAGAGGAAAGCGGGGAACCGUGUUUUCGCCGCCUCUGUAACCACUGCACACAAGAAAACCAGCUUCUGGGAGAGGGGGAUGAUUGUUGGGACUUUGCGAAUUACCUAAACAGCCCAGGGCCGAGGCGCCGCCGCUCGCGUCCUGGUCCUCCUGCCGGGUGUGGGGCUCCCCUGCCCGAGAUGGCCAGCGGGCGCGCCGAGAGUAUCCUGGAGCCAUCUAGUCUUGCCUCGGAGGCGGGGUGGGCUUAUUUGUGCGGAGAAGAAACGGAUCUCUUAAUGGGGUGAGAUUUUUCCUCCGUACAUUGUUCCCAUUUCCGCAGUUUCACUUGGCCUCGGUUUUCUAGCAGAGUAAUCACCAAAUGAAAUUAGCUGGAGAGCGUUUGAUGGCGCAGAAUCACGGUCUGAAGAUGUUUACGCUGUAUGCCGGACGCGUUUGAUGGUGUUCUCUUCGGCACAAUUAAUUUUGCAAAGUUCAGAAAUGUGCCAGACAGAGCCCCUGGCACGCAGUCAGGACUCUACAGACACACCUUGAGUAGGAAACAGGCUUGUUUGUUUCAUCUGUGAUUUAUGUGAUGCACCAGCACCAAGGCCAACGUGUUUUUUAAAGACCUUUCGAUGAAACUCCAAAGCAAUUUAUAAAUUGGCAAAAUGAAGCUUGUUUUGUAAAAUAACUCUUCCUUGUUGAUCAUGUAAUUAAAUGGGCAACAAAACACCUGAAAGGACAUUUACUGAAAAGUAGACUCCCAAAACAAAAAUAUGUAUUUCACAGCUAGAUACGGUCGCUAUUAGCGUCCUAAUGGCCAACUCCAUCCAUGUGCGUAUUUUGAACACUAAAAACGCCUCCUGUUACCCCUAAGACCUUGUUUGGAUAACAUUUUUCUAUUAUAAGUACUCGAAACCAACCCCAUUUAAGAUGUUUACCCUUAUUCUUGAGUCCUUGAUGGUUUGGGAAAUUUAUCAUUAUUCAUAUUGCACAAUCCUGUCACUGUCUUUUCCAUUAGGCACAGUGCCUAAGGUCCACAAUAUUUUUAGAGGCCCACAAAAAAUAUUUUAAUUUCUUUUCAAAUCAGAAGGAAAAAAAAUUUAGGUUUAAGAAAGUAUUUUAAUAUAUAUUAAUAUAUUUGUUUUUGUGCUAAUACAAUCUUAAAAUGUAUGUAUAUAUGUGUGUGUGUAUAUGUAUAUAUAUUUUAAUGGAGUAAGGGGCUCAACGAAGGCAAAAAGGCCUAGAGCCCAAGAAAAACAUGAUGUGGCCCUGUUGCCUGGGGUUGAAAAAUCCCAUUCCAUGAGAAGAAUUUAGUUUUAAGAAUAUUACAUAAAAUGCUCAUUUCUGUGGCCUUGCUAUAAUAGAAAGAUGGAGAUUCAGAGUAGUGAUAAUGGCUAACAUCCACCUGAUACACACCAUGUGUCCAUUACCUCUUAAUCCUCACAGCACACCUGUGAAAUAGGUACUAUUCUCACACUUAGGGGGUAAUGCAGGUUUUGUGGGGCCUGCAAUUUAUGCAAUUUGGGUGGUCCUCUUAAAGAAAAAGCAAAUACUGUGUAUUAGUCCGUUCUCACACUGCUAUAAAGAACUGCGCGAGACUGGGUAAUUUAUAAAGGAAAGAGGUUUAAUUGACUCACAGUUCCACAUGGCUGGGGAGACCUCAGGAAACUUAACAAUCGUGGUGGAAGGAGAAGCAAGUACCUUCUUCACAAGGAAGCGGAAAGAAUUGUGAGCGGAGGAACUUGCCAAACACAAAACCGUCAGAUCGCGUGAGAAUUCAGUUACUAUCACGAGAACAACACGGGAAAACUGUCCCCAUAAUCAAGUCAUUUCUCUCCCUAACAAGUGAGGAUUACAAUUCAAGAUGAGGUUUGGGUAGGAACACAAAGCCUGACCCUAUCCCACAGCAUGUCCAGGCUGCCCUAGCACCACCCAAUAGAAGGGAAAAUGGCAGAGGGAAAGUCCUAGUGGAAAGAGACCUCAGUCUCAGCUAAUUGUGGUGACAAUAUAUUGCUUUUGCAAAUUGUACAUAAACAUAUGACCAGGUGAAUGUAUCGCCAAGGCUCCUGCCAAGGCCUGGGAUGGAGGCCUAGAGAAGAUGCCCGAAAGUUUAUGCUGUGUGAGCUUCACAGAAGACCUGCCUUCCAUGUAUACCCAUUUUACAGGUGUCUGUGCGGUGCAGAAACUGUACAACUGUAUACAGUGACCAUUUCUACUCUGGGUCUCUAAACAAGGGCUGGUAUCGUUACAGAGACUGAAGACUGAGGAAGACCAUCUCUGUAGGAUGCCAAGGAUUGACUGGAGAAAGUCUGGCAGAAUAGAACGUCUUGCACAAGAGGAGUGGAACAGCGGUCAGAGCAUUACAGCUGACUCAUCUUGACCAGAGAAGGUUACAGCUGGAGGCCCCAGAGAUUGCCCACUUCCCCCCUCCAUUUGACAGCAAGGGAAACAAUGGCCAGAGAGGAUCUGGAACUUUCUCUCAAUUUCAGUGAAGGCCAGAGGUAAAAUCAGGAUUGUCUGAAGACAAGUAAGGUCAGGUGCAUAGGGUUAUAUGUAGGAGUAUAGUUAACAGGUGUCAGAAACUUGGAUUUAAUUUAGAGGUGGUUAGGACAUGCAUAAUAUUUUUCAACUAUGCGUGAAAUCUGGGAUUCUGCAUUUAUUUAAAAUAUAGGAUUGUCCAUUAAUUCUUUCUCUUGAGAGGGCGCUUCUUUCAGAAAUGAUCUAGGCACUUACAAACAUUUUAAAAAUAUAUACACGUGAGAUCAUACUUUCAUAGUGAUAUAAGCAUCAUUGCUCAUAUCCCUAAUGAACAGAUGGGGAAAAGGAGGUAGAGACAGAGAGAGAGACAGAGAGUCAGCAACUCACCACAAGAAUCUCCUGGUUGCCUGUCUGGGCUUCUGUCAGCUCCAUUUAGUUGAAUUUCUAUUCAAUAUUAUUACUGAGGUCUUAUACUUAAGAACAUGUUCUUUGGGUUUCCUGCUUAUCUCCAAGCUGAAGAAUUUAUUUUCUUCUAUUUGCUUUUCCAAUCUUCAGCUUCCAUGACCUUAAAAAAAAAAGUACACAAACUGAGCUGGUCUAAGAGCAGCCUGUUUGCAACCUGAUAUGAGACCUGGAAUGCAACCAGAUAAACCUUGGUGUAGGGUUCUCUAAACACAUUCAACAUUUUUUCCAAGAGGCAAUCGGUUUAUUUCCUUUGAAAUGCUUGAUGAUGAAUUAACAGUACAUUUUCGAAACUAUUGAAAGAGCAGAGGUAAAAUGGUAGUUAUACAUGUCGGAAUGGGAAAUAGAGAACUAUGGAAUUUAUCUUACUUUGAAGCUUAAACCCCUUUUAAUAUUCCUUGUAUUUAGCCACAUGUAUUUUUAAGGUGGAAAUUAGUUAAUGGAAUAUUCUCAUAGUCCAUACUUUUUAUUAAGGUUGAUGUUUGAUGAACCAGAUAAUGUCUACUCACUUUCUGCUUUAAAGUUUAUAAUUCUUGAUAAAAGGAAAAGUGGUGAAUUAUGUGAGCCAACCCUGGAAAGUAUUUCCGUAUUGAGUUUUGUUUGUUUCAAAGAACCUACUGUACAUAUGCAAAAAAA

Taxonomic tree

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Expression New Publications