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Homo sapiens (human) hsa-miR-378i URS0000480E22_9606

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hsa-mir-378i: Hsa-mir-378i is a microRNA that has been studied in various cancer types, including colon cancer, renal cancer, and hepatocellular carcinoma (HCC) [PMC8357504] [PMC5751259] [PMC8794677] [PMC6884461] [PMC10083302]. Reduced expression of hsa-mir-378i has been observed in stage II colon cancer and is associated with alterations in cell proliferation, cell-cell interaction, and apoptosis [PMC8357504]. In renal cancer, hsa-mir-378i was found to be significantly decreased under long-term hypoxia treatment, suggesting its potential role in renal cancer progression [PMC5751259]. In a study involving HCC patients, hsa-mir-378i was identified as an independent prognostic factor for poor survival. It exhibited a high hazard ratio (HR) of 18.34 and a p-value of 0.045 [PMC10083302]. Additionally, hsa-mir-378i was found to be highly expressed in various cancers including HCC and exhibited a 5-fold increased expression compared to normal tissues [PMC6884461]. These findings highlight the potential significance of hsa-mir-378i as a biomarker for the diagnosis and prognosis of different cancers. However, it is worth noting that another microRNA called hsa-miR-3180 showed an even stronger association with HCC patient clinicopathological characteristics compared to hsa-mir-378i [PMC10083302]. This suggests that both microRNAs may have important roles in cancer development and progression.

Genome locations

Gene Ontology annotations

Localisation

Sequence

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ACUGGACUAGGAGUCAGAAGG

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