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SNORD105: SNORD105 is a type of small nucleolar RNA. To investigate the effect of the rs2305789 polymorphism on SNORD105 expression, two SNORD105 vectors containing either the A or G allele were constructed and transfected into Huh7 and HepG2 cell lines [PMC8649375]. Reverse transcription primers for SNORD105 and U6 were designed and provided by Gene Pharma [PMC8649375]. The expression levels of SNORD105 and PPAN were examined in HCC tissue samples with different genotypes [PMC8649375]. A case-control study was conducted to evaluate the association between the SNP (rs2305789) within SNORD105 and HCC susceptibility in a Chinese population, as there is currently no research on polymorphism in SNORD105 and its function in HCC [PMC8649375]. The effect of SNORD105 on HCC cell proliferation was determined using an Enhanced Cell Counting Kit-8, following the manufacturer's instructions [PMC8649375].
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