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MIR1-2: MIR1-2, a microRNA, was found to induce differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) into cardiomyocytes by activating the Wnt/β-catenin signaling pathways [PMC5424345]. This study demonstrated that the over-expression of MIR1-2 in BMSCs effectively promoted cardiomyocyte differentiation with less cytotoxicity compared to the use of 5-aza, a commonly used differentiation inducer [PMC5424345]. Copy number assays were used to measure the expression levels of various genes, including MIR1-2 and other genes involved in cell cycle regulation and proliferation [PMC7083839]. The specific copy number assays used were as follows: MIR1-2 (Hs06506989_cn), CCND1 (Hs00377865_cn), CCND2 (Hs00394283_cn), CCND3 (Hs02982157_cn), CDKN1B (Hs02136152_cn), CDKN2A (Hs03714372_cn), CDK4 (Hs01071103_cn), and CDK6 (Hs00389416_cn) [PMC7083839]. These assays were purchased from Thermofisher, a well-known supplier of molecular biology reagents [PMC7083839]. Overall, this study provides evidence that MIR1-2 can effectively induce BMSC differentiation into cardiomyocytes through Wnt/β-catenin signaling pathways and suggests its potential as a therapeutic approach for cardiac regeneration [PMC5424345].
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