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Homo sapiens (human) microRNA hsa-mir-1 precursor (hsa-mir-1-2) URS0000447557_9606

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MIR1-2: MIR1-2, a microRNA, was found to induce differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) into cardiomyocytes by activating the Wnt/β-catenin signaling pathways [PMC5424345]. This study demonstrated that the over-expression of MIR1-2 in BMSCs effectively promoted cardiomyocyte differentiation with less cytotoxicity compared to the use of 5-aza, a commonly used differentiation inducer [PMC5424345]. Copy number assays were used to measure the expression levels of various genes, including MIR1-2 and other genes involved in cell cycle regulation and proliferation [PMC7083839]. The specific copy number assays used were as follows: MIR1-2 (Hs06506989_cn), CCND1 (Hs00377865_cn), CCND2 (Hs00394283_cn), CCND3 (Hs02982157_cn), CDKN1B (Hs02136152_cn), CDKN2A (Hs03714372_cn), CDK4 (Hs01071103_cn), and CDK6 (Hs00389416_cn) [PMC7083839]. These assays were purchased from Thermofisher, a well-known supplier of molecular biology reagents [PMC7083839]. Overall, this study provides evidence that MIR1-2 can effectively induce BMSC differentiation into cardiomyocytes through Wnt/β-catenin signaling pathways and suggests its potential as a therapeutic approach for cardiac regeneration [PMC5424345].

Genome locations

Gene Ontology annotations

Sequence

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ACCUACUCAGAGUACAUACUUCUUUAUGUACCCAUAUGAACAUACAAUGCUAUGGAAUGUAAAGAAGUAUGUAUUUUUGGUAGGC

Taxonomic tree

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This sequence is found in 56 other species

  1. Ailuropoda melanoleuca (giant panda) microRNA 1-2 (ENSAMEG00000022003.2)
  2. Aotus nancymaae (Ma's night monkey) miRNA (ENSANAG00000006769.1)
  3. Bos grunniens microRNA 1-2 (ENSBGRG00000015707.1)
  4. Bos mutus miRNA (ENSBMUG00000021938.1)
  5. Bos taurus microRNA bta-mir-1 precursor (bta-mir-1-2)
  6. Camelus dromedarius (Arabian camel) microRNA 1-2 (ENSCDRG00005019938.1)
  7. Canis lupus dingo microRNA 1-2 (ENSCAFG00020015904.1)
  8. Canis lupus familiaris miRNA (ENSCAFG00000020524.2, ENSCAFG00030018279.1, ENSCAFG00040000538.1, ENSCAFG00845015840.1)
  9. Capra hircus (Goat) microRNA 1-2 (ENSCHIG00000001719.1)
  10. Carlito syrichta miRNA (ENSTSYG00000020517.2)
  11. Catagonus wagneri (Chacoan peccary) microRNA 1-2 (ENSCWAG00000006141.1)
  12. Cebus imitator microRNA 1-2 (ENSCCAG00000009297.1)
  13. Cercocebus atys miRNA (ENSCATG00000015944.1)
  14. Chlorocebus sabaeus microRNA 1-2 (ENSCSAG00000021146.1)
  15. Colobus angolensis palliatus (Angola colobus) miRNA (ENSCANG00000010548.1, ENSCANG00000010583.1)
  16. Equus asinus asinus miRNA (ENSEASG00005002412.1)
  17. Equus asinus microRNA 1-2 (ENSEASG00005002412.2)
  18. Equus caballus eca-mir-1-1 (ENSECAG00000026408.2)
  19. Felis catus (domestic cat) microRNA 1-2 (ENSFCAG00000022149.3)
  20. Gorilla gorilla gorilla (Western Lowland Gorilla) microRNA 1-2 (ENSGGOG00000033290.2)
  21. Loxodonta africana microRNA 1-2 (ENSLAFG00000024772.1)
  22. Lynx canadensis microRNA 1-2 (ENSLCNG00005022156.1)
  23. Macaca fascicularis microRNA 1-2 (ENSMFAG00000006758.2)
  24. Macaca mulatta (Macaque) microRNA 1-2 (ENSMMUG00000035811.3)
  25. Macaca nemestrina miRNA (ENSMNEG00000000549.1)
  26. Mandrillus leucophaeus (Drill) miRNA (ENSMLEG00000003582.1)
  27. Microcebus murinus microRNA 1-2 (ENSMICG00000029392.2)
  28. Mustela putorius furo (Domestic ferret) miRNA (ENSMPUG00000022236.1)
  29. Myotis lucifugus miRNA (ENSMLUG00000028327.1)
  30. Neogale vison (American mink) miRNA (ENSNVIG00000017841.1)
  31. Nomascus leucogenys (Northern white-cheeked gibbon) microRNA 1-2 (ENSNLEG00000019814.2)
  32. Otolemur garnettii (small-eared galago) miRNA (ENSOGAG00000028881.1)
  33. Ovis aries Pri-miR1.2 precursor
  34. Pan paniscus (pygmy chimpanzee) microRNA ppa-mir-1 precursor
  35. Panthera leo (lion) microRNA 1-2 (ENSPLOG00000019192.1)
  36. Panthera pardus microRNA 1-2 (ENSPPRG00000013562.1)
  37. Panthera tigris altaica miRNA (ENSPTIG00000003368.1)
  38. Pan troglodytes (chimpanzee) ptr-mir-1-2 (ENSPTRG00000027778.2)
  39. Papio anubis (olive baboon) miRNA (ENSPANG00000030037.2)
  40. Piliocolobus tephrosceles (Ugandan red Colobus) miRNA (ENSPTEG00000035586.1)
  41. Pongo abelii (Sumatran orangutan) miRNA
  42. Prolemur simus (greater bamboo lemur) miRNA (ENSPSMG00000011176.1)
  43. Propithecus coquereli (Coquerel's sifaka) miRNA (ENSPCOG00000010616.1)
  44. Pteropus vampyrus (large flying fox) miRNA (ENSPVAG00000026326.1)
  45. Rhinopithecus bieti (Black snub-nosed monkey) miRNA (ENSRBIG00000020838.1)
  46. Rhinopithecus roxellana miRNA (ENSRROG00000028027.1)
  47. Saimiri boliviensis boliviensis (Bolivian squirrel monkey) miRNA (ENSSBOG00000001372.1)
  48. Suricata suricatta (meerkat) microRNA 1-2 (ENSSSUG00005015540.1)
  49. Sus scrofa microRNA 1-2 (multiple genes)
  50. Theropithecus gelada (gelada) microRNA 1-2 (ENSTGEG00000015706.1)
  51. Tursiops truncatus (bottlenosed dolphin) miRNA (ENSTTRG00000023641.1)
  52. Ursus americanus (American black bear) miRNA (ENSUAMG00000014031.1)
  53. Ursus maritimus miRNA (ENSUMAG00000019794.1)
  54. Ursus thibetanus thibetanus (Asiatic black bear) microRNA 1-2 (ENSUTTG00000000752.1)
  55. Vicugna pacos (alpaca) miRNA (ENSVPAG00000015670.1)
  56. Vulpes vulpes miRNA (ENSVVUG00000003967.1)
  57. Zalophus californianus (california sea lion) miRNA (ENSZCAG00015014953.1)
Publications