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mmu-miR-683: Mmu-mir-683 is a miRNA that has been found to interact with various circular RNAs (circRNAs) and participate in apoptosis-correlated pathways involved in the pathogenesis of ischemia-reperfusion (IR) injury [PMC6595412]. Oxygen-glucose deprivation/reoxygenation (OGD/R) has been shown to upregulate the expression of mmu-circRNA-015947, which interacts with mmu-mir-683 and other miRNAs, potentially regulating downstream gene expression [PMC5689704]. Bioinformatics analysis has revealed that mmu-circRNA-015947 can bind with mmu-mir-683 and other miRNAs, leading to the elevation of target gene expression [PMC7710414]. In the colon, mmu-mir-683 is potentially involved in regulating the expression of 200 upregulated genes [PMC3084815]. In rats with sciatic nerve injury (SNI), circRNA_2837 has been shown to sponge members of the miR-34 family, including mmu-mir-683, leading to autophagy induction and neuronal protection [PMC7326721]. Additionally, in HT22 cells subjected to hypoxia/reoxidation, upregulated mmu-circRNA-015947 interacts with mmu-mir-683 and other miRNAs associated with neural damage, potentially regulating target gene expression [PMC7326721]. These findings suggest that mmu-mir-683 plays a role in various cellular processes through its interactions with circRNAs and other miRNAs.
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