cfa-miR-9: Cfa-mir-9 is a dog brain HTE miRNA that shares sequence homology with rat and human and is a cross-species biomarker candidate for brain injury [PMC4989286]. It has been found that naturally occurring myxomatous mitral valve disease (MMVD) in dogs, which closely resembles MVP in humans, is associated with increased levels of plasma-associated exosomal cfa-mir-9 [PMC7696149]. Cfa-mir-9, along with cfa-miR-181c, cfa-miR-495, and cfa-miR-599, shows changes in expression levels during disease progression and development of heart failure in dogs [PMC5533140]. Cfa-mir-9 and cfa-miR-495 have common target genes such as AGFG1 and FAM126B, which are associated with fibrosis control, cardiomyocyte replication, energetics, cardiac fibrosis, cellular energy production, Ca2+ homeostasis or cardiac remodeling [PMC5533140]. MiRNA target predictions suggest a network involving cfa-mir-9 that deserves further attention [PMC5533140]. The expression of cfa-mir-9 appears to be age-related in dogs [PMC5533140]. In older normal dogs compared to young normal dogs or dogs with MMVD or MMVD-related congestive heart failure (MMVD-CHF), the expression level of cfa-mir-9 is low [PMC5533140]. CFA mir 9 has been found to be consistently elevated in various cancer cell types according to both NGS and qPCR analyses [PMC8379617]. The expression of cfa mir 9 correlates not only with disease progression but also with the age of the dog [PMC8400600].
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