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SNORD27: SNORD27 is a small nucleolar RNA (snoRNA) that plays a role in alternative splicing regulation. Transfection of col1a1-miR-29b resulted in a significant inhibition of SNORD27 expression, while transfection of CMV-miR-29b inhibited the expression of carnitine palmitoyltransferase 1b (Cpt1b) [PMC7746150]. Knockdown experiments using antisense oligonucleotides (ASO) showed that the snoRNA SNORD27 is crucial for alternative exon exclusion, as its depletion almost entirely abolished this process [PMC7200641]. Further minigene experiments, where the snoRNA targeting region was replaced, confirmed the requirement for a direct interaction between SNORD27 and its target [PMC7200641]. In terms of clinical relevance, recent reports have indicated that SNORD25, SNORD27, SNORD30, and SNORD31 are associated with the progression from smoldering to symptomatic multiple myeloma (MM) [PMC3766210]. These findings suggest that SNORD27 plays an important role in alternative splicing regulation and may have clinical implications in cancer progression.
mRNA interactions
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