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Homo sapiens (human) Smith-Magenis syndrome chromosome region, candidate 5 (SMCR5) URS000040501C_9606

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SMCR5: SMCR5 is a non-coding gene located in the Smith-Magenis Syndrome Chromosome Region [PMC9197456]. Overexpression of SMCR5 has been associated with poor outcomes in ovarian cancer [PMC7928381]. SMCR5 has been identified as one of the lncRNAs that regulate COL1A1 through sponging has-mir-143 and has-mir-98 [PMC7928381]. In a comparative analysis, increased expression of SMCR5 was observed in the responding group compared to the non-responding group [PMC9605465]. SMCR5 is one of the genes included in the magenta module, which consists of 1 differentially expressed lncRNA and 20 differentially expressed genes, and is potentially important for polycystic ovary syndrome [PMC7666708]. The expression levels of SMCR5 were significantly different between carboplatin-sensitive and carboplatin-resistant cell lines [PMC7928381]. In a risk score model, SMCR5 was included as one of the variables with a negative coefficient, indicating its potential association with risk prediction [PMC8993551]. The black module consisted entirely of differentially expressed genes, while the yellow module included 4 differentially expressed lncRNAs (including SMCR5) and 45 differentially expressed genes, suggesting their potential importance for polycystic ovary syndrome [PMC7666708]. References: - PMC9197456 - PMC7928381 - PMC9605465 - PMC7666708 - PMC8993551

Targeting miRNAs 17 total

According to LncBase, this RNA is targeted by the following miRNAs:

Genome locations

Gene Ontology annotations

Sequence

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AAUUCACUCAGGGCCUAAGAGCUUUGGGCAGUUAAAUCCCCCUCCCCGACAACAGACUAACAGGUCCCAUUUUGAUAUCAAGGGCUGGGGUUUCAAGACAGGGAACUGUGGGGCCCACGCUGUCCUGGCCUCCCUGGAGGCCUGGCUGCUCUCAUGCCAGGAAGGGAGCUUCCAUUUACUACGGGCCUAGGAUGGCCGCCCCGCUGCCCCCAGCGCUCCCUGGGUGGGUGCGGAUCCUGGCCAGUCCCCCAGACACGCAGUCUGCUGACCAGAAGCAGCGACCUUCGGGGAGAGCCAGCCACCAGCCAGCCACUGCUCCAGAGGCAGGCCUGGGGCCACCCGGGAGGCUUUCCUCACCACGGAAAAUAUUUGCCUUUGGUUGUCGGCUGAUGCCUUGUCUUGUGUCUGAAUGGACAACUGGCUGAUUUCUCUCUCUUUGGAACAGCCAUGAAAUGCGAAGGUGUUUAAGAGUAAAAACCAGGCGAGGGCAACUGGGCCUGGCGUCCAGCUGUUUUGAACAACACUCUUGUUUUUCUCCCAGAGUGAACAGAAUACUUUCUGCGGUUCAGAAUACUCUGUGCACUGGCCCCUCUUCCCAGGCCCCGCCCCAGCCCCCUCAGGCCUCACCUCCAGCUGCUGCAGACCAUUCCAGAACUCCCUCCCUCUUGGCUUCUAGUCACUCAGCAUCUGGGGGAGAGAGCCUCUUCCAGCUGUACAUAGCUAGCUUGGCCUGGCCCCAGAACUGCUGUGUUCUGGAAAGUUGUAGGAGAAUCCCUCUUGGCGGGCUCUCCAGCAUGGAGAAUCGCAGGCCUCUGCUCCGGAAAGGGAGGCUUUUGAGAGGUCAGAUUCACCACAGCCAGACCAAUGAACUGUGAGGGCUCAUAGGGGCUGGGGCUCCGGUUUCAGGGGUGAGAGGAGCCACCAUCUGCCCCCAUGCCCACUCUGAUUGUAAAUGGCUAGACUCUGGUGCCGGGGUCAGCUCUGGAUUCAUAUCCCAGCUCCUGCAUAUGUAUAUGCUGGGUGACCUUGGGCAGUUUACUUAACCUCUCUGUGCUUUGUGUGCCUAAGCUGCAAGAUACUCUAAAUUAAACAGCAAACUUUCAGUGCUGUUGUGGGACGAAAUGGGAUAAUGUGCUUGGUAGCUGGCAGGGGCUCAAUAAAAGGUAGCAACUUCCAGGGCCACCAGUUCAUGGGGAGCCAGGUCCAAGUCUUGUACUUUCUAUGCCUCCCAGGGAGCCACGUAUGUCUGCGACAGAGCUGGGGAGGACAUUCUGGGGCUGAGGGUUGAGGUCUGCCCAUAGAGCAGCGGCCUGUACCUGCAGGCAGGUAGAGUAUCAUCCUGGCUGAGUCUCAGUGCUCCUCAAACAUUAAAGUGUACAUCCUGGUGAGACGCAGAUUUUGAUGCAGCGGGUCAGGUGGGACAGGGGUUCUGCAGCUGUAAGGAACUCCCAGGUCAAGCCAGUGUGGCAGGUCUGUGACCGCAGCUGGUACGGCAAGAUCUCAGCCCUGGAAGACUCUGGGUUCUGCUGAGGCUGGGCUCAGAGAGAGAAUACAAGUUUUGUCCUGUCCAAGGAGCACCCUCCAGGAUUUCAGGACAAGGCUCUGGCUCUGUGUCCCCAAGCCCUCAGUCUCAGAGCUUGGGUCCUGCAGUGGCCUGGGCAACCCUCCGGACUCUCCAUUCAGCAUUUGUUCCUGACAGCAGUGCACGGAUAAAGAGCAGUUUCAUGCUGCUGAACUUGCAAUCACUUCAAGGCCUGGGCCCCUCUGGGCCUCAGUUUCCCCACUGGCACAGUGGGAAGCUGGGAUAAGCUAAUCCCACCCUUUCCCCUUGGUAAUUCCCCACAUUGCUCUUCCCUUCCCUUCAUCCCUUCCCAAAACACAGGUCUGAGGCCUGAGCAUCCAUCCUAGGGGCUGGGCCCCCAUCCCCAUGACUGCAGUCAUGGGGUACAAGACUCAUGCAGACUCGUAAGAACAGCCACUUCUGACCUGGGGCCUCGAUGUUCCAGGCACUGUCCUAGGCAUUUGCAUCUACAAACUUCUCACCAUAAUCCAAUCACCACUGUUUUACAGAUGAGGAAACUGAGCCCCACGGGGUGAAGCCUAUUGCCUGAGAUCUUGCAGUUGGUAACGGGUGCAGGCUGGACUCAGGCCCCCACACAUGCCCAGGCCCUUGAGUAUUUGUAAGGGAAGCAGCUGUUUGGUUUUCUUGGCACAGAGCAUCUGCCUAGCUGGUGAGGGCAUGGGGAAAGAGGUGCCCAAUCUAGUUGGGGAUGGGAGGGUAAAAUGGUACUACCUCUUUGGAGAGCUUUCUGGCAAUAUGGACCCAAAUGCAAAUUACAUGUGCCCUCUAACCUGGGCCCGAAGUCAUCUGCACAAGGCUACCAACUGCAAUGUCCUUUGCAGCAGCAAAACACGGGAUCCCCUAGCUGUCCAUCCAAGGGGGAUGAGGGAGAUACAUCUGGGAGGUUCUAUUGGCUGAGUACUCAGAGAAUGGAAGCACCACAUGGAUUAAUUGGAGCAGUCUUCAAGUUGGUGAAAAAAAGUGCAGUGUAGAAAGUGUGUACAGGGCCGGGUGCAGUGGCUCACACUGUAAUGCCAGCACUUUGGGAGGCUAAGGCAGGAGGAUUGCUUGAGCAUAGGAGUUUGAGACCAGCCUGGGUAACAUGGGGAGAUCCUACCUCUACAAGAAAAAAAAUGAACUAGGCAGGUGAGGUGGUGUUUGCCUGCGGUCCCAGCUACUUGGGAAGCUGAGGUAGGAGGAUUGCUUGAGCCCAUGAAGUCAGGCUGCAGUGAGCUGUGACUGCACCACUGCACAGUCUGGGCGACAGAGCAAGACCCUCUCUC

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Publications