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Homo sapiens (human) KLHL7 divergent transcript (KLHL7-DT) URS00003C5D0A_9606

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KLHL7-DT: KLHL7-DT is a differentially expressed long non-coding RNA (lncRNA) that has been identified as a prognostic-related gene in various studies [PMC9334800] [PMC10000590] [PMC9128282] [PMC7819609] [PMC7198905]. It has been found to be expressed in patients with laryngeal squamous cell carcinoma (LSCC) and is associated with the development of an immunosuppressive tumor microenvironment (TME) and resistance to checkpoint immunotherapy [PMC9128282]. KLHL7-DT, along with two other lncRNAs, BARX1-DT and LINC02154, has been identified as a hub gene and used to construct an IRL classifier for predicting prognosis, immune infiltration, and immunotherapeutic efficiency in LSCC patients [PMC9128282]. KLHL7-DT has also been found to be in moderate linkage disequilibrium with the GPNMB gene, which is associated with Parkinson's disease risk [PMC7819609]. In addition, KLHL7-DT has been identified as a potential target for seven protein-coding genes in LSCC [PMC7198905]. Overall, KLHL7-DT is an important lncRNA that plays a role in the prognosis and immune response of LSCC patients. It can be used as a potential biomarker for predicting patient outcomes and guiding personalized immunotherapy strategies.

Genome locations

Gene Ontology annotations

Sequence

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CACAGUGGCGCGCCGUUCCGAGCAAUGAGACUGCAGGCACAGGUGCGGCCGGAUUCCCUGUCGCUGUCCCGCGCUGAGUGAAUUUUGCCUCGGAGCUGGUCCGAGGUCGCGCCUGCUCUUUUGUGUGCCCAAGGCAGAUUUCCAGAAGUAGAAAUCUGUCUUCUAACUCUAAGGCCUUGGGAGAUGAAGGAUCCGUGAUUCAAAGGCAGAAAUAGAUGGAGUCUUGCUGUGUUCUCCAGGAUUGAGUACAGUGGCUUAUUCACAGAUGUGAUCAUACUACACUACAGCCUCAAACUCCCGGGGUCAAGCAGUCCUCCUGCUUCAGCCUCCUGAGGAGCUGGGACUACAGGCCCACAUCACCAUGCCCACUAGAUUCACAGUCAUUUUGCUUGUGGAAGGUCUUGCCUCAAUGUUGAUAGGUGCUGACUGAUCAGGGUCAGGUUGCUGACUGAUCAGAAUGGUAGUUUCUGAAUGUUGGGAAUGGCUAUGGCAAUUUCUUAAAAUAAGACAACAAUGAAGUUUGCUGCAUUGAUUGACUCCCUUUCACAAAGGAUUUCUCCAUAUCAUGCAAUGCUGUUUGAUAGCAUUUUACCCAUAGUAGAACUUCUUUCAAAAUUGGAGUCAAUUCUCUCAAACCUUGUCUCUGCUUGGUCAACUAAGUUUAUGCACUAUUCCACAUCCUUUGUUGUCAUUUCAACAAUAUUUACAGAGUCUUCACCAUGAAUAGAUUCCUUUUCAAACAACCACUUUCUUUGCUCAGCCAUAAGAAGCAACUCUUCACCCAUUCAAGUUUUAUCAUGAGAUUGCAGCAAUUCAGUCACAUCAAAUUCCACUUCUAAUUCUAGUUGUUUUUCUAUUUCCACCACAUCUGCAGGUACUUUCUCCACAGAAAUUUCAAACCUCUCAAAGUCAUCCGUGAGGGUUGGAAUCAACUUCCAAAUUUCUGUGAAUGUUGAUAUUUUGACCUCCUCCUAAUCACAAAUGUUCUUAAUGGCAUCUAGAAUGGUGAAUCUUUUCCAGAAGGUUUUCUAUGUGCUUUGCCCAGUUCCAUCAGAAGAAUCACUGUCUGUGGUAGCUCUAGCCUUAUUAAAUGUAUAUUUUAAAUAAUAACACCUAAAAAUCAAAAUGACUCCUUGAUCCAUGGGCUGUAGAAUAGACAUUGUGUUAGCAGUCAUGAAAACAAGAUUAAUCUCCUCAUAUAGCACCAUUAUAGCUCUUGGGUGACCACGUGCAUUGUCAAUGACCAGUAAUAUUUUGAAAGGACACCUUUUUUUUUGAGCAGUAGGUCUCAACAGUGGACUUAAAAUAUUCAGAAAGCUGUGUUGUAAACAGAUGUGCUGCCAGCUAGGUAUCGUUGUUCCAUUUAUAGAGCACUGGUAGAGCAGAUUUAGCAUAAUUUGUCAGGACCCUAGGAUUUUUGGAAUGGUAAAUGGGCACUGGCUUCAACUUCAAGUAACCAACUGCAUUAACUCCUAACAAGAAGAGUCAGCCUGUCCUUGAAAGUAUGAAAACAGGCAUGGACUUCUCCUCUCUAGCUAUGAAAGUCUUAGAUGGCAUCUUCUUCCAAUAGAAGUUGUUUCAUGUACAUUGAAAAUCUGUUGUUUGGUGUAGCCACCCUCUUCGAUGAUCUUAGCUAGAUCUUCUGGAUAACUUGCUACAGUUUCUACAUCAGCACUUGUUGCCUUACCUUACACUUUCAUGUUAAGGAGAUAGCUUCUUUCCUUAAACCACAGGAACGAACCUCUGCUAUCUUCUAGAUUUUCUUGGGCAACUUCCUUACUUCUUUCAGCUUUCAUAGAACUGAAUAGUGUUAGGAUCUUGCUCUGGGUUAGGUUUUGGCUUAAGGGAAUGUGGUAGCUGGUUUGAUUUAUUUAGACCACUAAAACUUUCUUCAUAUCAGCAUUAAGGCUGGUUUGCUUUAUUAUCAUUUAUGUGUUCACUGGAGUAGCACUUUAAAUUUCCUCCAAGCUUGUUUGCUUUUCACUCACAGUGUGGCUGUUUGGUGCCAAGAGGCCUAGCUUCCCAGUCUUGGCUUUCAACAUGCCUUCCUCACUAAGCAUAGUCAUUUCUAGCUAUUUAUUUAAAGUUAGAGAUGUGCAACUCUUCUUUCACUUGAACACUUAGAGGCUAUUGUAGGGUUAUUACUUGGCUUAAUUGCAAUAUUGUUGUGUCUGGAGGAAUAGAGAGGCCUGGGGACACAAAGAGAAAUGGGGAACAGCUGGUCACUGGAGCAGUGAGAACACACGCAACAUUUAUUGAUUAAAUUCGCUGUUUUAUGGGCUCGGUUCAUGGUGCUCCAAAACAAUUAUAAUAGUAACAUCAAACAUCACUGUUCACAGGUCACCAUAACAGAUAUAAUGAUAAUGAUAAUAAUAAUAAUGUUUGAAAUAUUGCAAGAAUUACCAAAAUGUGACUCAGAGAAACAAUAAAGUGAGCACAUGCUGUUGGAAAAAUGGUACUGAUAGACUUGAUCCAUGCAGGGUUGCCACAAACGAUUAAUUUGCAAAAAAAACAAACAAAAGAACAUGCAGUAUCUGUGAAGCACAAUAAAGCAUACUGCAAAU

Taxonomic tree

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Publications