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Homo sapiens (human) NKX2-1 antisense RNA 1 (NKX2-1-AS1) URS00003B5B5C_9606

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NKX2-1-AS1: NKX2-1-AS1 is a long non-coding RNA (lncRNA) that has been implicated in the regulation of PD-L1 expression in lung cancer [PMC8305593]. A study has revealed that NKX2-1-AS1 is involved in the regulation of genes responsible for cell adhesion and migration in lung tumor cell lines [PMC6158174]. This finding contradicts a previous study by Balbin et al., which suggested that NKX2-1-AS1 plays a role in cell growth [PMC6158174]. However, the down-regulation of NKX2-1-AS1 using siRNAs resulted in changes in cell number over time, indicating its involvement in cell growth [PMC6158174]. Furthermore, overexpression of NKX2-1-AS1 has been shown to reduce cell migration and immune system evasion by decreasing the expression of CD274, which encodes PD-L1 [PMC9712323]. Interestingly, it has been observed that NKX2-1 and NKX2-1-AS1 do not have a direct reciprocal transcriptional regulatory relationship [PMC6158174]. These findings highlight the multifaceted role of NKX2- 11 AS11 and its involvement in various cellular processes.

Genome locations

Gene Ontology annotations

Sequence

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ACUUUCUUGUAGCUUUCCUCCAGGGGACUCAAGAUGUCAGACACUGAGAACGGAGUCGUGUGCUUUGGACUCAUCGACAUGAUUCGGCGGCGGCUGGAGGAGGAAGGAAGAGGAGGAAAAAAAAGGGAGAGGGGGAAGGCGAAGCCUCGCUGCUUUUUUUUUCUCCCUUUGCCAAAUAUUCUGGUGUUACCUUAACGCCGAUCUUGUUGGAUGUACACGUAACGGAGUGGACCGAGUCCUCCUUAAUUGGCUUGAGUGGAGGCUCGGGGGCUGCCUCGCGUUUGUUUUAGCCCGGCGCCAGGUUUUAGGCAGCCACCAGAGGCGGGGCGUAAGCGCUAAAGCAACAAGACAAUAGAAGCCUACAUCUUGCCCGAGAUAAUUAGCUUACAUGCUGAUGACAAGGGUAAAGAAAGCUCAGGACACCCUCCGCCCUCCCACCUGCGCCCGCGUUUUUGUGCGGUCCCCACGGCAGAGCUGGGGAGGCCACCCUACGUUUGCGCAGGGAGACGCGCUCGCCGCUGGUGUUGCGAAAGACCAGAGCGAAGCCCGGCUCCUUGCCCUUCCUUCCCAGGGGCUUCUCUGGGGGGCGCUCUCAGGCCCCGACGAACUGAGCAUUGAUCACUGUGGUGGCUAAGCAAGGAGGGGAGGCGACGCCGGGCUUAAGCGAACCACAGAGGAGAACUGGCAACGCUGAAUACAGACCUUGUCUGCAGGCGCGACCUGGCCGGGCCUGAGUCCCGAAUGGGGUCUAAUUGCGAAGGCGGGGUGGGUUUCCCAGUCACCCAGCUUCUUUCUCUCACUCGCCAUUAUUUCAUAGUUGUUUGUAAGUUUAAGGAACACCAAGUGUAGAAUGUUGUACAUCUCUUCCAGUCUCAACGCCAUUUAGAAAUGGAGAUCAAUCUUCACAAGGUUUUUGUGAGAUUCAAGUAAGAUGAAGCACAUCAAAAUGCUUUGAAAGCUUUGAAUGUUUUUCAGCUCAGUGCCAGCACUGGAGAUUGCGGUAGUUAUUAUCAUGACUAUCCCCACCCCCUCUUAGGUCCCAAGACCUGAGUAAAAGGAAGAGUUGGGUGAAUCUUCCACAGCCCCUAGGUCCUGUCUUCUCGGCCUUCGUCCCUUGGCAGCUUUUCAACCUCUCAGCAGGCCACAGGCGCACGUGGCUGGCAGCUCCCCGGCCUCCGGCUCUGACAGUCCGGGGGCAACCAGGCCUGCAGUUCUCGAGGAAACCCCCAGCCCCCCACGUCUCGUUCUGGACCAGGAACCCCCUCCCCAACAACCGCGCAGCAAGUGGCGACUCUGGGAGCUGAACUGGAGUGGAGCUCGAAGUGGCUGGGGCGGGCAAAGACUCCCGCUUCACUCUGGGACACAACUGGGACGGCGCUUCAACCUCUGCCUGCAGGCGUGCUUCUCGCGCGCACCAGCAAGCUCUCUAUCCACCUCGCCUGGGCCUUUGCAGCGCCCUGCCGCCCAGGCUCCAGCGCCUCUACUACCCUAGCCCCUUCUCAACACGCGGCUCUGCCUUCUUCCCCAGUACCACUGCACUGCCGAAAAUAAGCCCGGAGACUAACGCACCUUGUAGGGAAGAGAAGGACAUCUGUAUCUCCAAGCUUAUCCAAGCAAAGGCCUCCAGAGUCCCUCCCAUGGCCCGAAACACCUCCCUCUGACCGAAGAGCGUCCUUUCUUUCCGCCGCCUCCUGGACUCAUCCUAAAUAGGGCAGACCCGGGCUAAACCAGUGAUUUUUUUUUCCAUGAAUACGAAGAACCCCGAUUGCACUUUG

Taxonomic tree

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Publications