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Homo sapiens (human) microRNA hsa-mir-154 precursor secondary structure diagram

Homo sapiens (human) microRNA hsa-mir-154 precursor URS00003AF18B_9606

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MIR154: MIR154 is a microRNA that belongs to the MIR154 family [PMC7794215]. It is transcribed from the maternal chromosome and is part of the Dlk1-Dio3 imprinted domain [PMC3919614]. MIR154 has been implicated in fibrosis of various organs [PMC7794215]. It has also been identified as a diagnostic biomarker for discriminating pulmonary granuloma and adenocarcinoma [PMC9400731]. In HPV16-positive cervical carcinoma, MIR154 is down-regulated compared to normal cervix samples [PMC4288222]. In T and B lymphocytes, the expression of MIR154 is decreased [PMC6122344]. The expression of MIR154, along with other genes in the imprinted domain, can be affected by Snail overexpression in tumors [PMC6122344]. SNP rs1700 overlaps with the predicted binding site for MIR154, suggesting its involvement in myocardial fibrosis and regulating metastatic behavior in lung cancer cells [PMC6465659]. The miR655 miRNA cluster contains several miRNAs including MIR154 that are overexpressed in medullary thyroid carcinoma samples [PMC7465874]. Overall, these findings highlight the importance of MIR154 in various biological processes and its potential as a diagnostic biomarker [PMC7794215, PMC3919614, PMC9400731, PMC4288222, PMC6122344, PMC6465659, PMC7465874].

Genome locations

Gene Ontology annotations

Sequence

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GUGGUACUUGAAGAUAGGUUAUCCGUGUUGCCUUCGCUUUAUUUGUGACGAAUCAUACACGGUUGACCUAUUUUUCAGUACCAA

Taxonomic tree

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2D structure Publications