rno-mir-665: Rno-mir-665 is a microRNA that has been studied in various contexts. In HSC-T6 cells, overexpression of lnc-BIHAA1 led to a significant decrease in the expression of rno-mir-665, along with rno-miR-667-5p and rno-miR-742-3p, suggesting a ceRNA regulation mode [PMC9331515]. In mice exposed to sevoflurane, the expression of miR-101b-3p was down-regulated, indicating its potential as a molecular target for preventing sevoflurane-induced cognitive impairment [PMC9331515]. On the other hand, propofol was found to up-regulate the expression of rno-mir-665 and induce neurotoxicity through negative regulation of BCL2L1 and increased caspase-3 expression [PMC9331515]. Rno-mir-665 is also involved in ceRNA networks associated with DEGs in the PI3K-AKT signaling pathway and is down-regulated in this context [PMC8636738]. Additionally, rno-mir-665 is highly expressed in an aluminum-exposed group and its related genes, circRNAs, and lncRNAs are lowly expressed [PMC8636738]. Rno-miR-101b-3p is decreased while rno-mir-665 is increased after aluminum treatment, indicating their importance as core molecules in ceRNA networks associated with DEGs [PMC8636738]. Furthermore, rno-mir-665 has direct targets in the VEGF signaling pathway [PMC5270432]. Overall, these studies highlight the involvement of rno-mir-665 in various biological processes and its potential as a therapeutic target.