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Bos taurus (cattle) bta-miR-193a-5p URS0000367985_9913

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bta-mir-193a: Bta-mir-193a is a differentially expressed (DE) microRNA (miRNA) in bovine mammary epithelial cells stimulated with S. uberis in vitro [PMC4065264]. It is generated from bta-mir-193a-2 and is reversely complementary to bta-mir-193a-3p [PMC4029070]. Bta-mir-193a, along with other miRNAs such as bta-miR-200c, bta-miR-210, and let-7e, has been identified as DE in response to S. uberis and LPS in other species [PMC3589390]. It has been found to be down-regulated at 4 hours post-infection (hpi) [PMC3589390]. Bta-mir-193a has been identified as a drug target for bovine disease and a potential regulatory marker for bovine trypanosomosis diagnosis and treatment [PMC6722470]. It is highly conserved across different species ranging from human to zebra [PMC6722470]. Bta-mir-193a has been shown to regulate the expression of proinflammatory cytokines, promote apoptosis, inhibit bacteria, and be involved in Toll-like receptor signaling during trypanosomosis infection [PMC6722470]. It is also significantly involved in gene silencing and RNA-induced silencing complex processes [PMC6722470]. In the context of host-virus interaction, bta-miR-29b and bta-mir-193a have been found to be down-regulated upon CPIV3 infection and likely participate in MDBK cells' response to the virus [PMC5885596]. However, the expression levels of bta-miR-2333 and other miRNAs close to bta-mir-193a were not significantly overexpressed in cultured myoblast cells transfected with the expression vector OPmiR-365-3p [PMC7802253].

Genome locations

Gene Ontology annotations


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This sequence is found in 19 other species

  1. Anolis carolinensis Aca-Mir-193-P1b_5p (mature (guide))
  2. Canis lupus familiaris cfa-miR-193a
  3. Cavia porcellus (domestic guinea pig) cpo-miR-193a-5p
  4. Cervus elaphus (red deer) cel-miR-193a-5p
  5. Chrysemys picta bellii Cpi-Mir-193-P1b_5p (mature (guide))
  6. Dasypus novemcinctus dno-miR-193a-5p
  7. Equus caballus (horse) eca-miR-193a-5p
  8. Gallus gallus (chicken) gga-miR-193a-5p
  9. Homo sapiens hsa-miR-193a-5p
  10. Macaca mulatta mml-miR-193a-5p
  11. Ophiophagus hannah (king cobra) oha-miR-193-5p
  12. Oryctolagus cuniculus (rabbit) ocu-miR-193a-5p
  13. Pongo pygmaeus (Bornean orangutan) ppy-miR-193a-5p
  14. Pteropus alecto (black flying fox) pal-miR-193a-5p
  15. Python bivittatus pbv-miR-193a-5p
  16. Sarcophilus harrisii Sha-Mir-193-P1b_5p (mature (guide))
  17. Sphenodon punctatus Spt-Mir-193-P1b_5p (mature (guide))
  18. Sus scrofa (pig) ssc-miR-193a-5p
  19. Taeniopygia guttata (zebra finch) tgu-miR-193b-5p