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Aedes aegypti (yellow fever mosquito) aae-miR-981 URS00003674BD_7159

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aae-mir-981: Aae-mir-981 is a crucial hub gene involved in three important chitin metabolism pathways that are highly enriched in all developmental stages [PMC9878986]. It is a node with the highest connectivity in the regulatory network of "alanine, aspartate, and glutamate metabolism" [PMC9878986]. Aae-mir-981, along with aae-miR-375, is conserved in all developmental stages and can be targeted to disrupt the normal molting process and control mosquitoes and mosquito-borne diseases [PMC9878986]. It has the highest connective degree among all nodes [PMC9878986]. A subnetwork of aae-mir-981 consists of 277 nodes (7 circRNAs, 268 lncRNAs, and 1 mRNA) with 276 edges [PMC9878986]. Additionally, Wolbachia infection induces the expression of aae-mir-981 and downregulates importin β-4 in wMelPop-CLA infected Aag2 cells [PMC8261290]. The subnetwork of aae-miR-375 and aae-mir-981 provides valuable information for exploring their extensive regulatory roles as hub genes [PMC9878986]. These findings highlight the importance of aae-mir-981 in chitin metabolism pathways and its potential as a target for mosquito control strategies.

Genome locations

Gene Ontology annotations

Sequence

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UUCGUUGUCGACGAAACCUGCA

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This sequence is found in 20 other species

  1. Bactrocera dorsalis (oriental fruit fly) bdo-miR-981
  2. Blattella germanica (German cockroach) Bge-Mir-76_3p (mature (guide))
  3. Cochliomyia hominivorax mature cho-miR-981
  4. Cochliomyia macellaria (secondary screw-worm) mature cma-miR-981
  5. Culex quinquefasciatus cqu-miR-981
  6. Daphnia magna Dma-Mir-76_3p (mature (guide))
  7. Daphnia pulex dpu-miR-981
  8. Dinoponera quadriceps dqu-miR-981-3p
  9. Drosophila ananassae Dan-Mir-76_3p (mature (guide))
  10. Drosophila melanogaster (fruit fly) dme-miR-981-3p
  11. Drosophila mojavensis Dmo-Mir-76_3p (mature (guide))
  12. Drosophila pseudoobscura dps-miR-981-3p
  13. Drosophila pseudoobscura pseudoobscura miRNA FBtr0330793_df_nrg
  14. Drosophila simulans Dsi-Mir-76_3p (mature (guide))
  15. Drosophila virilis dvi-miR-981-3p
  16. Drosophila yakuba Dya-Mir-76_3p (mature (guide))
  17. Heliconius melpomene (postman butterfly) hme-miR-981
  18. Manduca sexta mse-miR-981
  19. Polistes canadensis pca-miR-981-3p
  20. Tribolium castaneum tca-miR-981
Publications