gga-mir-206: gga-mir-206 is a muscle-specific miRNA that has been identified in chickens [PMC7797159]. It has been found to affect preadipocyte proliferation and differentiation in chickens [PMC9258119]. The overexpression of gga-mir-206 inhibits adipogenesis by downregulating its target gene, Kruppel-like factor 4 (KLF4) [PMC9258119]. gga-mir-206 has also been found to be differentially expressed in embryonic skeletal muscle tissues between meat-type broilers and egg-type layer chickens [PMC4849015]. It is the most abundant miRNA in skeletal muscles of broilers and layers, consistent with its role in skeletal muscle development [PMC3107184]. gga-mir-206 has also been identified as a target of circRNA derived from the RBFOX2 gene [PMC5824844]. It is associated with genes such as ankyrin repeat domain 1 (ANKRD1), ankyrin repeat domain 12 (ANKRD12), MAFF, FOS, osteocalcin-like protein OC3 (OC3), phytate kinase 2 (IP6K2), and Cyclin C (CCNC) [PMC9689937]. The expression of gga-mir-206 is downregulated by miR-M2-5p, resulting in the upregulation of Pax3, Bcl-2, and Bcl-xL and inhibition of CEF cell apoptosis [PMC7669912]. The expression of gga-mir-206 has also been confirmed by real-time RT-PCR [PMC3496578]. In addition to its role in muscle development, gga-mir-206 has also been found to target the FoxO signaling pathway and the MAPK signaling pathway in chickens [PMC6815035].
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