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cfa-miR-1: Cfa-mir-1 is a type of microRNA that is involved in ventricular remodeling in humans [PMC4490541]. However, in left ventricle cardiomyocytes from dogs, the expression of cfa-mir-1, along with cfa-mir-133 and cfa-miR-208, was not altered [PMC4490541]. In veterinary patients with congestive heart failure (CHF) after experimental ventricular pacing, various changes in miRNA concentrations have been observed. These include the downregulation of cfa-mir-1, cfa-miR-26a/b, cfa-miR-29a, cfa-miR-30a, cfa-mir-133a/b, cfa-miR-208a and cfa-miR-218 and the upregulation of cfa-miR-21 and cfa-mir146b [PMC5533140]. Cfa-mir-1 is also found in the heart and skeletal muscle of dogs along with other miRNAs such as CFA mir133a/b and CFA mir208 [PMC4989286]. In a study evaluating miRNA biomarkers for various tissues including liver (cfa mir122), heart/muscle (cfa mir1), muscle (cma mir133), pancreas (cma mi216) and brain (cma mi212), no significant changes were observed in the levels of non-liver enriched miRNAs including CFA mir 1 when compared to control dogs [PMC4989286]. Additionally, transient serum elevations of heart/muscle TE miRNAs such as CFA mir 1 were not correlated with microscopic findings and may be due to injury during animal handling [PMC4989286]. Histopathological analysis did not identify microscopic changes in heart or muscle tissues when compared to control dogs [PMC4989286]. In a qPCR validation study, cfa-mir-1 was selected as a biomarker candidate for heart/muscle toxicity [PMC4989286].
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