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hsa-mir-122: Hsa-mir-122 is a microRNA that plays a significant role in the occurrence and development of lung adenocarcinoma [PMC8943533]. This microRNA and its related genes offer potential targets for the targeted therapy of lung cancer and other types of tumors [PMC8943533]. In the context of microRNA-gene networks, hsa-mir-122 is identified as one of the key microRNAs, along with hsa-miR-570, hsa-miR-34b, hsa-miR-29c, hsa-miR-922, and hsa-miR-185 [PMC4121398]. These microRNAs negatively regulate approximately 79 downstream target genes that are involved in modulating hepatocyte immune response, inflammatory response, and glutathione metabolism [PMC4121398]. The regulation of these processes by these key microRNAs suggests their potential role in modulating tumor development and progression [PMC4121398]. The identification of these key microRNAs provides new insights into the molecular mechanisms underlying lung adenocarcinoma and offers potential targets for therapeutic interventions [PMC4121398]. By targeting these specific microRNAs or their downstream target genes, it may be possible to modulate immune response, inflammatory response, and glutathione metabolism to inhibit tumor growth or enhance therapeutic efficacy [PMC4121398]. These findings contribute to our understanding of the molecular mechanisms involved in lung adenocarcinoma development and provide new avenues for targeted therapy research [PMC4121398].
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