hsa-mir-4458: Hsa-mir-4458 is a microRNA that has been identified in various studies. It has been found to be differentially expressed in different groups, such as the EFL1 and EFL2 groups [PMC9608949]. Hsa-mir-4458 has also been shown to have interactions with lncRNAs, such as CBR3-AS1, NPTN-IT1, CDKN2B-AS1, and SNHG4 [PMC6509943]. Additionally, hsa-mir-4458 has been identified as a target for HMGA2 [PMC8485123]. It is hypothesized that the expression of hsa-mir-4458 may have an impact on pro-inflammatory responses and the maintenance of intestinal epithelial barrier integrity [PMC7466023]. Hsa-mir-4458 has also been found to target genes associated with child obesity traits [PMC9092671]. In the context of PEX glaucoma and NTG, hsa-mir-4458 demonstrated opposite expression patterns between the two conditions [PMC9007941]. Furthermore, hsa-mir-4458 has been shown to target genes involved in glioma regulation [PMC9784332]. Other miRNAs that have interactions with hsa-mir-4458 include hsa-let7f5p and hsa-miR302a3p [PMC6874787]. In terms of IR treatment-related genes, hsa-miR-4458 targets FAS gene expression [PMC8021574]. Overall, these studies highlight the potential role of hsa-miR-4458 in various biological processes and disease conditions.