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Homo sapiens (human) ZFAT antisense RNA 1 (ZFAT-AS1) URS0000323138_9606

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ZFAT-AS1: ZFAT-AS1 is a non-coding antisense RNA gene that overlaps with the ZFAT gene and is expressed from the paternal chromosome in the human placenta [PMC7866243]. It has two exons, with the second exon partially overlapping with ZFAT exon 7 [PMC3466192]. Both ZFAT and ZFAT-AS1 are imprinted in the human placenta, with expression from the paternal alleles [PMC3466192]. In a study involving placental cDNAs, it was found that only the paternal allele of ZFAT-AS1 was expressed [PMC3466192]. The expression of ZFAT-AS1 was found to be much lower than that of ZFAT [PMC3466192]. In glioma cells, ZFAT-AS1 has been shown to mediate histone H3 methylation on lysine 27 in a PRC2-dependent manner to promote transcription of CDX2 and facilitate malignant behavior [PMC9405925]. The interaction between DGCR8/ZFAT-AS1 and CDX2 has been implicated in glioma progression [PMC8226164]. DGCR8 can also decrease lncRNA ZFAT-AS1 expression by attenuating its stability and induce its cleavage, promoting malignant behavior in glioma cells [PMC9363451]. The encoded protein of ZFAT, a DNA binding protein, functions as a transcriptional regulator involved in cell survival and apoptosis [PMC4464490]. In addition to its role in glioma progression, lncRNA ZFAT-AS1 can also induce H3K27me3 gene-specific deposition to promote epigenetic silencing [PMC9843056]. Overall, seven new genes were identified as presenting monoallelic expression along with ZFAT-AS1 [PMC3515015], which participates in diverse cellular processes [PMC9247704].

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Gene Ontology annotations

Sequence

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GAGACCUACCAAGAACCAUGUGGUUGCUGUUAAUGACCAACUACAACAAAAUGGGCAACCCCAGGCAGUGGUGAGAAUGUGGGCUUGAAUUCUGUCUCUGUCCCUUACCAAUGGCACAACCAUGAGCAAGUUACCAAACGACUCUGUAAUGCCAGGCCCCUAAUCUGCCCAGUGGAGGAAAUACUCCAACUCCUAGAAGUAAUAUGAGAAUUAAGACUGCACAAGGAGCUGACCCACAGGAUAAAGACAGCAGCUGUUCCUUCCCUUUCCCCCAACAUGUAUUUCCCCAGAUGCCAUCCUACAUGUUCACAUUGAAGAGAUAAGCCUCUCAGAAGGAAGAUAACCAUAGAAAGUUGAAAAGAGAAACCUCUUUAGAUGCUGGUUUAUUAAGAAGAAUGAAGGCAGAUGUGACUGGGGCCAAAGAUCUCAGUGCACAUUCCUGACACUCCCCCACUGAUCAUGAGGCCCAAGGAUGUGGCCAGGAGGCCGAGCAUCAGCAGCUGGGAGACUCUUGCUGUGAAAGGAACCUGGGAAGCCUCUGCCACGUGCACAGCUGUGUAAGGAGAAGGAUCUCUCUAUGUUUUCAGGGCUGACCUGCAGCAGAGACACCUACAUAUAAGCAUAAACUUGAGAAAGCAAUGAGCACCCAGGGGAGACGGGGCUGCCGCUUGGGCUUGCUACUUACCAGUGCUGUGUGAACUUUAAGAUGUGCCUGUAGCUUAUAUUUAUCUGGAGUUGAGUAGUCACAGCCAUCGGUGGGACACUUCAGCAAGAUGUUACUGUGUUUCUGAAUUACGUGGCGUUUAAGGCAGUUUUUGGUGAUGGAAGAAUAAUGACACUGAGAGCAAUAAUACAGAUGUUCCCGGGUGUGGGUGCGGACAUGCAUAUCAAAAUGCACUUGGUACCAAAAAAGUUUGCCUAAAAAAAUAUUUUCACAUG

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