hsa-mir-34c: Hsa-mir-34c is a member of the hsa-miR-34 family, which consists of hsa-miR-34a, hsa-miR-34b, and hsa-miR-34c. These members have highly homologous sequences and share similar target genes and functions [22]. The hsa-miR-34a gene is located at chromosome 1p36, while hsa-miR-34b and c are cotranscribed as part of the same gene cluster located at 11q23 [23]. Studies have shown that hsa-mir-34c is downregulated in various tumors, including breast cancer and prostate cancer, where it functions as a tumor suppressor gene [24][25]. In non-small cell lung cancer (NSCLC), miR-34c is expressed at low levels. However, overexpression of miR-34c in NSCLC cells can inhibit proliferation, induce apoptosis, and inhibit invasion or metastasis [26]. The clinical significance of miR-34c expression in NSCLC-derived exosomes has not been extensively studied. Additionally, the molecular mechanism underlying the development of NSCLC has not been fully elucidated [27]. In a study on chronic pancreatitis (CP), three upregulated differentially expressed microRNAs (DEmiRs) were identified: hsa-miR-206, hsa-mir-34c, and hsa-miR-484. These DEmiRs were found to potentially target NOTCH3 [28].