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bta-mir-222: Bta-mir-222 is a differentially expressed (DE) miRNA that has been identified in various studies. It has been found to be shared between different groups in a Venn diagram analysis [PMC10000098]. Bta-mir-222 has also been detected with different abundance levels in cows at embryo transfer [PMC5662615]. In addition, it has been shown to suppress certain genes as targets, such as PSTPIP2, VAV1, and SOCS3 [PMC8928958]. Bta-mir-222 is among the DE miRNAs that have functions related to mastitis [PMC8928958]. It has also been found to be upregulated in extracellular vesicles (EVs) from competent embryos and downregulated in EVs from arrested embryos [PMC7727673]. Furthermore, bta-mir-222 has been identified as one of the DE miRNAs associated with SF groups and its expression was found to be upregulated in mastitis-affected cows [PMC4156418] [PMC6008395]. Bta-mir-222 is also involved in lipid metabolism and its downregulation affects lipid metabolism-related differential miRNAs [PMC8850724]. It has been detected at low levels or not detected at all in the ovarian cortex, while its expression was exclusively found in cumulus cells [PMC2762473]. Moreover, bta-mir-222 plays a role in viral infection by targeting interferon regulatory factor 2 (IRF2) and affecting interferon-I expression and CPIV3 replication [PMC9228844]
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