v24

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Homo sapiens (human) GATA6 antisense RNA 1 (head to head) (GATA6-AS1) URS00002AE1E3_9606

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GATA6-AS1: GATA6-AS1 is a long non-coding RNA (lncRNA) that has been studied in the context of cardiac differentiation and its role in inhibiting cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) [PMC9227037] [PMC7532887]. Proteomic analysis has identified molecular pathways, including MAPK, PI3K/AKT, WNT pathways, and Akt/mTOR signaling pathway, that are related to GATA6-AS1 [PMC7532887]. EMT is associated with tumor cell migration and invasion as well as cancer stem cell properties [PMC7184168]. GATA6-AS1 has been shown to inhibit EMT through the Wnt/b-Catenin signaling pathway in gastric cancer [PMC7184168]. However, the relationship between GATA6-AS1 triplex sites and TADs specification is not yet established [PMC9227037]. Deficiency of GATA6-AS1 leads to downregulation of definitive endoderm signature genes and blocks stem cell differentiation and cell fate commitment [PMC7486217]. In lung cancer cells, the expression of GATA6-AS1 was detected using RT-qPCR method [PMC7533243]. In gastric cancer tissues from patients, GATA6-AS1 expression was significantly lower compared to paracancerous tissues [PMC7335301]. References: [PMC9227037] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9227037/ [PMC7532887] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532887/ [PMC7184168] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184168/ [PM7486217] - https://www.ncbi.nlm.nih.gov/pmc/articles/PM7486217/ [PMC7533243] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533243/ [PMC7335301] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335301/

Genome locations

Gene Ontology annotations

Sequence

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AACCCCCGCCUAGCCCCUUCACAGCAAAUGCGCUUUUUGCCCUGAAGUUGUGUGAGACCGACCUUAAACUUUCUCCGACCCUAUCUCGGGAUGCUACGGCUCAGGUCGUGGUGGUUUCGGGAACCUCAAGACAACAUUCCCCAGCUGACCUUUGGGAACUUUAACUCGGGUCGUCAUGUACGGAAAGGUAGUCUAUGGGGUACGCAGAAUGGAAAAGGGCUUCCACAUCAGUCGUGUCCGAGGACGCUCUCCAACUUUUGAUGUCCCUGGAGAGUUUCUGAUAUUUCCCUGGAGAGUUUCAGAAAGGAUUUCUUCCGACAGACGUGACCCCAGAAGGCUGCCGAGGGAGACUUUAGGACAAGAGGCGUUGUUUUUGUGAGAAUGAAUUUUUAUACUUUACCCCGACCCCACCCCCUACCCCCCGCCCAGGUAAAUCCAAGUAAAUGAUUUUCUGAAGGUCGGUCUCCUAGAAAGCGUUUAGGCUCUGGUUUUUUGUUUUGUUUCUAUUUUCGUGUUUUCCCAGUUAGGGAAGGAAGAGGAGCCUGUGCAGAGUUGAACUGGGGUGGAGAGGUGCCUUGUAAAGUAUGGUUUCCAGAGAUGGUGAGACCUCGUAGCUAAGCGUUGUUUCCUCUGCACGUAACUGUGAGUUGUGAACUUGUGGCUCCUGGGGGAGCGGGACAGGGCCUGGCAGUGCGGGGGAGGGGGCAAGGAAUUCAGGAAGUUGGCGAGAAUUCUUCGUUUUUCAUUCUUCGUUGUAAAUUGCUUCUAAACACUUCUGAAUUUUAAAUUGCUACCGAGAAGGUCCAGAAACCGUUCUCAUCCAAUUUAGUCACUUUUAUUACGUUCCACUUUGCCUCCCCCAAUCACUGCGGCGGCUCCCAGUUUCAGCGUGGCCGCAUUUGGAAAAGGCUGAAGGUAGAAAACUCUGGAAUGGAGAGGCUGGCGACUGGAGCAGGAUCCAGGGGCUUUAAAUUUUAACCUGAAUGCGAUCGAAUGCGCGACUCCCAGAAGAGAUAGCCAGGCGUCCGCCCGGCCGCUCAACCCCCGCCAGGACUCGGAAUGCCUUGCUUUUGGUUCUUUUCGUGAGUUCCGACCAAAUGUUUAAGUGGACUGGGUUUUGCAGAAGCUCAUUUGUAAGCACUGACGGAAAUGGGUUGUGGGCAUUUGAUUUCCUUUGAUUCCAACGUUUUGAAAUAAUGUUUCUCGGAUUUGCUAUUCGAAGCAAUUUUCUAAAAACUCAUAUCUUAUUUGCUAAAAAUAAACUCUUUGGCUCAGUUUGUGUCCAGGCUGUGUACGGCCUCCAACCCUGAGCCCCGAGGAGAUCGAGCCCUGGCGCGAGCCUGAUCUCUGUCCUGUGUGUUUCUUUGUAUUUGCAAGUACAAGGAUGUCUGCGUGGAUAUCCCUGGACACUCGAUACCCCCCGGGGACCUGCUUUUCCCGCAGCUCCGCAGACGCGGCGGGAGGGCGCGCUGGCCCCGGCGCUGCUGGGACAGAGGUGAGCAGCGGGGUGGACAUUGACCGAUUCGACAACGUUCGGGCUCUAAGGGCUCGGGAAGGGACCCGGCAUUUUACCCUCCAGAUUCCCAAUCUAUUUUUAAAAAUAAUGUUCAAAACAUAUGGGAAAAAUAAGUGAUUGCUCCUUUUCAUGGUCACAGAUUGUAUUUAUUUUUUCAGACUGGUUUUCCAACCUAACGAGGGAAUGGGUAGUGAAUGUUGUUGUUGUUGUUGUUGUUUAUGUUGGUUAAUUUCGAAAUAAAACUGUUUAACUCGUACAGUUGAUUCAGACAG

Taxonomic tree

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Publications