bta-mir-451: Bta-mir-451 is a differentially expressed circular RNA (circRNA) that has been found to have regulatory relationships with various targets, including AC_000178.1_22528, AC_000169.1_14270, bta-miR-154b, and bta-mir-451 itself [PMC8946036]. It is one of the top 10 highly expressed miRNAs in all samples and has been identified as a potential biomarker for mastitis [PMC6107498] [PMC5821052]. Bta-mir-451 has been implicated in the regulation of ATF2, CDKN2D, and MEF2D [PMC5821052]. It plays different roles in the regulatory mechanisms of mastitis caused by S. aureus and E. coli infections, being up-regulated in S. aureus infected mammary glands but down-regulated in E. coli infected mammary glands [PMC5821052]. Bta-mir-451 has also been found to be up-regulated in large healthy follicles compared to small follicles [PMC5821052] [PMC6731312]. It is involved in immune responses and targets MO25 to alter AMPK signaling [PMC6600136]. Furthermore, bta-mir-451 has been detected in mammary glands infected with Staphylococcus aureus and is differentially expressed during parturition [PMC6600136] [PMC9445238]. It is also highly expressed in rumen fluid but not among the top 10 most expressed miRNAs in papillae samples [PMC9378797]. Overall, bta-mir-451 plays a significant role in various biological processes and may have potential applications as a biomarker or therapeutic target.