gga-miR-204: gga-mir-204 is a highly conserved miRNA that is found to be almost three-fold more abundant in R+ animals compared to R- animals [PMC4256448]. It is also significantly upregulated in chicken under feed deprived conditions [PMC4256448]. gga-mir-204 has been shown to block insulin production by downregulating MAFA, an insulin transcription factor, in pancreatic beta-cells [PMC4256448]. It is one of the miRNAs that are differentially abundant between feeding conditions and also exhibits significant differential abundance for the Line contrast [PMC4256448]. The target genes of gga-mir-204 are involved in processes such as antigen processing and presentation, apoptosis, and chronic myeloid leukemia pathway [PMC4735322]. Additionally, gga-mir-204 has been found to be expressed in VVs and its expression levels have been measured using qRT-PCR [PMC10014936]. In a study comparing different miRNAs expressed in CD30hi lymphocytes, gga-mir-204 was found to be increased [PMC3472249]. In another study comparing LP and LCa groups, gga-mir-204 was upregulated in LP group and its target genes were enriched in various metabolic pathways [PMC8241840]. Furthermore, gga-mir-204 has been predicted to interact with EDN-3 using the stem-loop sequence of the miRNA [PMC5390260]. References: [PMC4256448]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256448/ [PMC4735322]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735322/ [PMC10014936]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014936/ [PM3472249]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3472249/ [PMC8241840]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241840/ [PMC5390260]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390260/