hsa-mir-3065: Hsa-mir-3065 is a microRNA gene that has been studied in various contexts. It has been found that both hsa-miR-338-5p and hsa-miR-338-3p can be accurately mapped to the opposite strand of hsa-mir-3065, indicating that both strands of a specific genomic region can generate the same or different mature miRNAs [PMC3102724]. In a study analyzing the miRNA expression profile dataset of pancreatic adenocarcinoma, hsa-mir-3065 was identified as one of the significantly differentially expressed miRNAs [PMC8821103]. It was found to be upregulated in diabetic pancreatic cancer, along with other miRNAs such as hsa-mir-301a, hsa-mir-205, and hsa-mir-592 [PMC8821103]. Hsa-mir-3065 was positively correlated with Endocrine and negatively correlated with Endothelial, Fibroblasts, and Plasma in tumor tissues [PMC8821103]. Additionally, it was found to affect the growth of melanoma cells through multiple antitumor effects [PMC8821103]. In terms of prognosis, high expression of hsa-mir-3065 was associated with poor relapse-free survival in pancreatic cancer patients [PMC8821103][PMC7378055]. Hsa-miR-146b is another microRNA associated with poor relapse-free survival in pancreatic cancer patients [PMC7378055]. References: [PMC3102724]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102724/ [PMC8821103]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8821103/ [PMC7378055]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378055/ [PMID3535683]: https://pubmed.ncbi.nlm.nih.gov/3535683/

hsa-mir-338: Hsa-mir-338 is a microRNA gene that is highly conserved among vertebrates and is associated with the prognosis of diffuse large B-cell lymphoma (DLBCL) [PMC7298280]. It is encoded by the introns of the AATYK gene and has distinct origins, with hsa-mir-657 originating after the primate-rodent split and hsa-mir-1250 originating after the human-chimp split [PMC3544654]. The methylation levels of hsa-mir-338 correlate positively with LINE-1 methylation levels, as well as with hsa-miR-27b and hsa-miR-486, while it inversely correlates with hsa-miR-34a [PMC3817343]. Hsa-mir-338 can indirectly regulate certain signal transduction pathways or directly target potential genes to regulate tumor cells' proliferation and invasion [PMC6753923]. It has been found that LINC00460 and LINC00525 are upregulated in lung adenocarcinoma (LUAD) and can improve the levels of FAM111B and ZWINT via hsa-mir-338 sponge, promoting cancer occurrence [PMC8997540]. Hsa-mir-338 interacts simultaneously with AATK in certain pathways [PMC8798414]. While MAFA-AS1 interacts with 36 genes, hsa-mir891a interacts with 11 genes, no gene shows interaction with hsa-mir338 [PMC7298280]. Additionally, five microRNAs including hsa-mir223, hsa-miR301b, hsamir383, and hasmir424 are associated with overall survival in lung squamous cell carcinoma (LUSC) patients [PMC6753923]. Finally, five microRNAs including hasmiR375 have been identified as having significant differentiation and statistical significance in RT-PCR experiments under sorafenib treatment [PMC7197942].