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SNORA69: SNORA69, also known as U69, is a small nucleolar RNA (snoRNA) that has been identified as the most up-regulated snoRNA in individuals with more severe autism spectrum disorder (ASD) symptoms [PMC8235321]. The exact role of SNORA69 in ASD is not yet known, but its up-regulation suggests that it may be involved in the pathology of the disorder [PMC8235321]. Manual inspection of novel regions also revealed that SNORA69 overlaps with other snoRNAs, a predicted novel miRNA, a known miRNA not in miRBase, and a small zinc-finger protein [PMC4875694]. In addition to SNORA69, other snoRNAs such as SNORD42A (U42) have been identified as the most down-regulated snoRNAs in individuals with more severe ASD symptoms [PMC8235321]. The dysregulation of these snoRNAs suggests that they may play a role in ASD pathology and warrants further investigation [PMC8235321].
References:
- [PMC8235321]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235321/
- [PMC4875694]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4875694/
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