dme-mir-34: dme-mir-34 is a miRNA found in Drosophila melanogaster. It has multiple targets in zygotic mRNA transcripts [PMC3632126]. The mammalian homologue of dme-mir-34 is associated with cell cycle regulation and is implicated in various cancers [PMC3632126]. LNA against dme-mir-34 was used to detect its expression in unfertilized Drosophila oocytes [PMC3632126]. In higher organisms, such as fish and mammals, the miR-34 family has diversified to include miR-34a, b, and c, while Drosophila has a single paralogue of miR-34 [PMC3632126]. dme-mir-34 is maternally inherited and important for neurogenesis in Drosophila melanogaster [PMC5852578]. It is also involved in metamorphosis development along with other miRNAs such as Dme-let-7, Dme-miR-100, Dme-miR-125, and Dme-miR-14 [PMC5689003]. The shorter isoforms of dme-mir-34 are enriched with Ago1 protein while the longer isoforms are not associated with any Ago proteins [PMC3268580]. The 21nt isoform of dme-mir-34 is the most abundant at adult stages in D. melanogaster [PMC3268580]. It has been found to modulate aging and neurodegeneration in flies [PMC4462583]. Additionally, dme-mir 11 and dme mir 184 are also implicated in photoperiodism and diapause along with dme mir 34[ PMC9100521].