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SNORD75: SNORD75 is a small nucleolar RNA (snoRNA) that has been studied in the context of lung cancer and its role in RNA processing. Analysis of a small cohort of lung cancer patients using RNA-seq revealed that the level of SNORD75 was significantly decreased in the plasma of lung cancer patients compared to healthy donors [PMC7140444]. SNORD75 is also encoded within the introns of Gas5, along with other box C/D snoRNAs [PMC6856654]. It contains an element for binding splicing regulatory factors, and its deletion can lead to alterations in Gas5 pre-lncRNA maturation [PMC6856654]. Mutations in SNORD75 may prevent the formation of the proper K-turn structure, as observed in monoclones obtained from experiments [PMC6856654]. Additionally, a consensus "DRACH" motif is found within the deleted region of SNORD75 [PMC6856654]. Furthermore, a piRNA derived from SNORD75 has been shown to bind PIWI proteins and facilitate histone mark exchange [PMC8508363]. These findings suggest that SNORD75 plays a role in RNA processing and may have implications for lung cancer.
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