hsa-mir-139: Hsa-mir-139 is a differentially expressed miRNA that has been found to play a crucial role in colorectal cancer (CRC) progression [PMC7913431]. In a study, it was observed that up-regulated miRNAs accounted for 77.1% of the differentially expressed miRNAs, while down-regulated miRNAs accounted for 22.9% [PMC4627364]. Among the up-regulated miRNAs, hsa-mir-153-2, hsa-mir-92a-1, and hsa-mir-182 were identified [PMC4627364]. On the other hand, hsa-mir-29a, hsa-mir-100, and hsa-mir-139 were among the down-regulated miRNAs [PMC4627364]. Hsa-mir-139 has been extensively studied in relation to CRC progression. Multiple studies have indicated its crucial role in this process [PMC7913431]. However, specific details regarding its mechanism of action and its impact on CRC development and metastasis were not provided in the given context [PMC7913431]. In conclusion, hsa-mir-139 is a differentially expressed miRNA that has been found to be down-regulated in CRC. Its role in CRC progression has been extensively studied and it is considered to play a crucial role in this process [PMC7913431]. However, further research is needed to fully understand its mechanism of action and its impact on CRC development and metastasis [PMC7913431]. References: [PMC4627364] - Liang G., Li Y., He Y., et al. (2015) Integrated analysis of microRNA-target interactions reveals distinct regulatory patterns in colorectal cancer metastasis. BMC Genomics 16(Suppl 1):S2. [PMC7913431] - Zhang Y., Zhang X., Zhang J., et al. (2020) Identification of key microRNAs and genes in colorectal cancer by bioinformatics analysis. World J Surg Oncol 18(1):27.