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SNORA40: SNORA40 is a small nucleolar RNA that belongs to the H/ACA box snoRNA family [PMC9413531]. It has been found to be overexpressed in the context of Huntington's disease (HD) compared to non-HD cases, along with other snoRNAs [PMC9413531]. In HD patients, SNORA40 has been shown to be downregulated, along with its host gene TAF1D [PMC8629011]. A mutation in SNORA40 in humans has been found to result in the formation of a modified form of 28S rRNA [PMC6984369]. SNORA40 has also been found to acquire a "compensatory" guide activity when another snoRNA, SNORA25, loses its specificity for 28S rRNA [PMC6984369]. It has been suggested that SNORA40 may play a role in the overall upregulation of the translational machinery in HD tumors [PMC3511933]. Additionally, SNORA40 has been identified as a potential therapeutic target for multiple myeloma [PMC8538251], asthma [PMC4391585], and multiple sclerosis [PMC4391585]. Overall, SNORA40 is an important snoRNA with potential implications in various diseases and biological processes [PMC4391585].
mRNA interactions
2 total
Genome locations
Gene Ontology annotations
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Sequence
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