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eca-miR-128: Eca-mir-128 is a microRNA that targets the gene CXCL16, which is involved in the persistence of Equine Arteritis Virus (EAV) infection [PMC9559303]. It has been detected in seminal plasma extracellular vesicles (EVs) of infected stallions [PMC9559303]. In-silico analysis using TargetScan identified eca-mir-128 as the most significant differentially expressed microRNA (DEmiR) [PMC5748701]. DESeq2 analysis identified eca-mir-128 as one of the 11 statistically significant DEmiRs, along with other miRNAs such as eca-miR-744, eca-miR-197, and eca-miR-103 [PMC5748701]. TargetScan database revealed 212 potential target genes for eca-mir-128 [PMC5748701]. In a comparison between edgeR and DESeq2 analyses, it was found that eca-mir-128 was not significantly affected by hemolysis levels [PMC5748701]. In a study involving long-term carrier stallions infected with EAV KY84, no differences were observed in terms of neutralizing antibody levels, viral output in semen, and gene expression profile in the ampullae among these stallions [PMC6692045]. EAV long-term persistence is associated with upregulation of CXCL16 and downregulation of eca-mir-128 in seminal exosomes [PMC6692045]. Eca-mir-128 has also been implicated in muscle cell proliferation, differentiation, and energy expenditure [PMC9498731]. Furthermore, it has been shown to regulate airway remodeling and CD4+ T cell maturation and differentiation in an equine model of severe asthma [PMC8372030].
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