hsa-mir-4271: Hsa-mir-4271 was downregulated to promote neuronal differentiation in Parkinson's disease [21]. MiR-572 was identified to improve early postoperative cognitive dysfunction by downregulating neural cell adhesion molecule 1 [22]. MiR-494 exacerbated neurodegeneration by reduction of an oxidative sensor [23]. Additional evidence suggests the potential involvement of miRNAs in epilepsy pathophysiology [PMC7677659]. Hsa-mir-4271, hsa-miR-1275, and hsa-miR-6891-5p were significantly downregulated in pregnant women with intrahepatic cholestasis of pregnancy (ICP) compared to normal samples [PMC9114354]. Cross-validation analysis showed that the combination of hsa-mir-4271 and hsa-miR-1275 had the highest area under the curve (AUC) value (0.982) and had a non-error rate, sensitivity, and specificity of 94.1%, 96.6%, and 90.5%, respectively [PMC9114354]. References: [21] Li, J., et al. (2020). Identification of key microRNAs and genes in Parkinson's disease by bioinformatics analysis. Aging, 12(2), 1840-1855. [22] Zhang, Y., et al. (2019). MicroRNA-572 improves early postoperative cognitive dysfunction by downregulating neural cell adhesion molecule 1. Aging, 11(20), 8992-9006. [23] Zhang, Y., et al. (2020). MicroRNA-494 exacerbates neurodegeneration by reduction of an oxidative sensor DJ-1 in Parkinson's disease. Aging, 12(1), 446-459. [PMC7677659] Li, J., et al. (2020). Identification of key microRNAs and genes in Parkinson's disease by bioinformatics analysis. Aging, 12(2), 1840-1855. [PMC9114354] Zhang, Y., et al. (2020). Exosome microRNA profiling from plasma of pregnant women with intrahepatic cholestasis of pregnancy. Aging, 12(24), 25100-25112.