hsa-mir-130a: Hsa-mir-130a is one of the miRNAs that may regulate TNF-α expression, according to a study that used a cut-off criterion to identify potential regulators [PMC7675078]. This study identified a total of 13 miRNAs that may regulate TNF-α expression, including hsa-mir-130a, hsa-miR-599, hsa-miR-130b, hsa-miR-454, hsa-miR-301a, hsa-miR-301b, hsa-miR-19b, hsa-miR-19a, hsa-miR-181a, hsa-miR-181b, hsa-miR-181c, and hsa-miR 181d [PMC7675078]. Additionally, the study identified two miRNAs that may regulate TNFR1 and TNFR2: HSA-MIR 335 and HSA-MIR 495 [PMC7675078]. Another analysis incorporated a 3 miRNA model consisting of HSA-MIR 193a , HSA-MIR 21 , and HSA-MIR 130a signature. This model showed a decreasing AUC to 0.84 ±0.021 [PMC9700700]. Overall these findings suggest that HSA-MIR130A is one of the potential regulators of TNF-alpha expression and could be part of a multi-gene signature for predicting disease outcomes or therapeutic responses related to TNF-alpha signaling pathways [PMC7675078] [PMC9700700].