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SNORD42B: SNORD42B is a small nucleolar RNA (snoRNA) that has been analyzed using the ΔΔCT method after normalization to human beta 2 microglobulin (B2M) [PMC5828204]. In a study conducted on primary splenocytes, the queuine modification status of SNORD42B was examined using the capture-release method followed by quantitative RT-PCR [PMC8136771]. SNORD42B was also subjected to validation in FFPE tissues of non-small cell lung cancer (NSCLC) patients, where its differential expression was identified [PMC9701848]. In addition to SNORD42B, other controls such as cel-miR-39-3p, SNORD69, SNORD61, SNORD68, SNORD96A, RNU6-2, miRTC, and PPC were included in the study [PMC4941693]. The expression of both SNORD42B and another snoRNA called SNORD111 in plasma remained stable and consistently measurable after treatment with Ribonuclease A (RNase A) or storage for 30 days [PMC9701848]. The levels of both snoRNAs were found to be significantly upregulated in NSCLC patients and were suggested as potential non-invasive diagnostic markers for NSCLC and early-stage NSCLC [PMC9701848]. Therefore, plasma levels of both SNORD42B and SNORD111 could serve as promising diagnostic biomarkers for NSCLC [PMC9701848].
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