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Homo sapiens (human) hsa-miR-3168 URS000020C393_9606

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hsa-mir-3168: Hsa-mir-3168 is a microRNA that is highly expressed in corneal epithelial stem cells (CESCs) [PMC7198595]. It, along with hsa-miR-21-5p, hsa-miR-150-5p, and hsa-miR-1910-5p, has a higher expression in the limbal basal epithelial layer compared to the corneal basal epithelial layer [PMC7198595]. While hsa-mir-3168 and hsa-miR-7-2-3p are upregulated in β cells but not in retinal ganglion cell (rGBC), there is no proven link between these microRNAs and the β cell program [PMC5558938]. Hsa-mir-3168 was tested but showed no amplification along with other microRNAs such as hsa-miR92a3p, hsa-miR148a3p, hsa-miR184, hsa-miR323b3p, hsa-miR4865p, and hasmiR12473p [PMC9738832]. Hsa-mir3168 along with other microRNAs such as hasmiRNA21 5P and hasmiRNA143 3P showed greater than seven-fold increase in expression in enriched CESCs compared to corneal central epithelial cells (CCECs), indicating their specificity to stem cells [PMC7198595]. In liquid biopsy samples, it was found that hasmiRNA29b15P, hasmiRNA4748P, hasmiRNA515 5P ,hasmiRNA548j 5P ,and hasmir65025P were upregulated while hasmir3137 and hasmir3168 were downregulated. However the relative expression pattern was not specified [PMC10094565]. Among the 77 downregulated miRNAs, hasmiRNA3137 and hasmir3168 had an AUC (Area Under the Curve) greater than 0.6 [PMC9140062].

Genome locations

Gene Ontology annotations

Sequence

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GAGUUCUACAGUCAGAC

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