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cfa-miR-125b: Cfa-mir-125b is a canine miRNA that has been studied in relation to canine chronic lymphocytic leukemia (CLL) and canine influenza virus resistance [PMC3619122] [PMC9917093]. In CLL, four miRNAs, including cfa-mir-125b, were found to be upregulated in both human and canine B-CLL [PMC3619122]. Cfa-mir-125b has also been associated with host cell resistance against canine influenza virus [PMC9917093]. However, its role in canine tumors has not yet been identified [PMC9917093]. In dog pituitary samples, cfa-mir-125b is part of the miRNA families with the highest activity, including cfa-miR-30 and cfa-miR-7 families [PMC4768678]. The 5' seed regions of cfa-mir-125b are partially complementary to the mRNA of avian influenza H3N2 virus proteins NP and NS1 [PMC8779696]. Additionally, in testicular samples with RA intervention, miRNA families such as miR-200, Mirlet-7, miR-125, miR-146, miR34a/b/c were significantly upregulated [PMC4049822]. Overall, cfa-mir-125b has been found to be upregulated in CLL and associated with host cell resistance against canine influenza virus. However its role in tumors is still unknown. It is also part of highly active miRNA families in dog pituitary samples. The 5' seed regions of cfa-mir-125b are partially complementary to avian influenza H3N2 virus mRNA. Additionally other miRNA families have been found to be significantly upregulated with RA intervention.
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