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aae-mir-125: Aae-mir-125 is a microRNA that has been found to be significantly upregulated in CHIKV-infected Ae. [PMC7690852]. It is one of several microRNAs that are highly expressed in both uninfected and infected Ae. [PMC5951587]. Aae-mir-125 is also highly expressed in the saliva of CHIKV-infected Ae.albopictus, with a read count of 4333 [PMC4303268]. MicroRNA inhibitors have been designed based on the sequence of aae-mir-125, along with other select microRNAs, to study their effects [PMC4303268]. In CHIKV-infected Ae.aegypti saliva, aae-mir-125 is also highly expressed with a read count of 15735 [PMC4303268]. Aae-mir-125 and aae-mir-100 are suggested to play a role in regulating immune cell activity at the bite site and influencing CHIKV replication [PMC4303268]. In comparison to uninfected saliva, aae-mir-2940 is downregulated while aae-mir-125, along with other microRNAs such as aae-mir-263a and aae-mir-100, are upregulated in CHIKV-infected Ae.albopictus saliva [PMC4303268]. Similarly, in CHIKV-infected Ae.aegypti saliva, highly expressed microRNAs include not only aae-mir-125 but also other microRNAs such as aae-miR-bantam and 263a [PMC4303268]. These findings suggest that these highly expressed microRNAs may play important roles in the response to CHIKV infection.
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