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Ovis aries (sheep) microRNA oar-mir-29b precursor (oar-mir-29b-1, oar-mir-29b-2) URS00001E96DA_9940

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oar-miR-29b: Oar-mir-29b is a microRNA that is involved in the regulation of various biological processes in sheep, including curly fleece growth and testicular development [PMC5948824] [PMC10035661] [PMC8017185]. It has been shown to interact with other microRNAs, such as oar-miR-22-3p, oar-miR-23a, and oar-miR-30a-5p, to regulate SIRT1 and follicular development [PMC5948824]. Oar-mir-29b is downregulated in sheep testes with the progression of age, and its expression negatively correlates with the expression of circ_024949, circ_026259, and IGF1 [PMC8017185]. Circ_026259 has been found to inhibit oar-mir-29b in Sertoli cells and promote the expression of IGF1 [PMC8017185]. In addition to its role in testicular development, oar-mir-29b has also been implicated in modulating the expression of CD80 and CD86 [PMC9428447]. The expression patterns of circ_024949, circ_026259, oar-mir-29b, and IGF1 are similar in various testicular cells including germ cells, Leydig cells, and Sertoli cells [PMC8017185]. The regulatory effect of circ_026259 on IGF1 expression through oar-mir-29b has been confirmed using luciferase reporter assays [PMC8017185]. Overall, this research provides insights into the role of oar-mir-29b in sheep testicular function and its interactions with other molecules involved in this process [PMC8017185].

Genome locations

Gene Ontology annotations

Sequence

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CUUCUGGAAGCUGGUUUCACAUGGUGGCUUAGAUUUUUCCAUCUUUGUAUCUAGCACCAUUUGAAAUCAGUGUUUUAGGAG

Taxonomic tree

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This sequence is found in 48 other species

  1. Aotus nancymaae miRNA (ENSANAG00000012107.1)
  2. Artibeus jamaicensis (Jamaican fruit-eating bat) microRNA aja-mir-29b precursor
  3. Bos taurus microRNA bta-mir-29b precursor (bta-mir-29b-2)
  4. Capra hircus chi-mir-29b (ENSCHIG00000001857.1)
  5. Carlito syrichta (Philippine tarsier) miRNA (ENSTSYG00000022228.2)
  6. Cebus imitator microRNA 29b-2 (ENSCCAG00000014462.1)
  7. Cercocebus atys miRNA (ENSCATG00000019703.1)
  8. Choloepus hoffmanni (Hoffmann's two-fingered sloth) miRNA (ENSCHOG00000014458.1)
  9. Colobus angolensis palliatus miRNA (ENSCANG00000004080.1)
  10. Cricetulus griseus miRNA (ENSCGRG00000021452.1, ENSCGRG00001008126.1)
  11. Dipodomys ordii (Ord's kangaroo rat) miRNA (ENSDORG00000021638.2)
  12. Equus caballus (horse) microRNA eca-mir-29b precursor (eca-mir-29b-2)
  13. Gorilla gorilla gorilla ggo-mir-29b-2 (ENSGGOG00000031229.2)
  14. Gorilla gorilla (western gorilla) microRNA ggo-mir-29b precursor (ggo-mir-29b-2)
  15. Homo sapiens microRNA hsa-mir-29b precursor (hsa-mir-29b-2)
  16. Ictidomys tridecemlineatus miRNA (ENSSTOG00000016717.1)
  17. Loxodonta africana (African savanna elephant) microRNA 29b-2 (ENSLAFG00000025291.1)
  18. Macaca mulatta microRNA mml-mir-29b precursor (mml-mir-29b-2)
  19. Macaca nemestrina microRNA mne-mir-29b precursor
  20. Mandrillus leucophaeus (Drill) miRNA (ENSMLEG00000009487.1)
  21. Mesocricetus auratus (Golden Hamster) microRNA 29b-2 (ENSMAUG00000007122.1)
  22. Microcebus murinus (gray mouse lemur) microRNA 29b-2 (ENSMICG00000019155.3)
  23. Microtus ochrogaster microRNA 29b-2 (ENSMOCG00000010775.1)
  24. Mus caroli microRNA 29b-2 (MGP_CAROLIEiJ_G0007004.1)
  25. Mus musculus microRNA mmu-mir-29b precursor (mmu-mir-29b-2)
  26. Mus pahari microRNA 29b-2 (MGP_PahariEiJ_G0007532.1)
  27. Mus spretus microRNA 29b-2 (MGP_SPRETEiJ_G0007342.1)
  28. Myotis lucifugus (little brown bat) miRNA (ENSMLUG00000028668.1)
  29. Nannospalax galili (Upper Galilee mountains blind mole rat) microRNA 29b-2 (ENSNGAG00000002522.1)
  30. Nomascus leucogenys microRNA 29b-2 (ENSNLEG00000026040.2)
  31. Ochotona princeps miRNA (ENSOPRG00000018053.1, ENSOPRG00000018405.1)
  32. Otolemur garnettii miRNA (ENSOGAG00000017450.2)
  33. Pan paniscus (pygmy chimpanzee) microRNA ppa-mir-29b precursor (ppa-mir-29b-2)
  34. Panthera pardus (leopard) miRNA (ENSPPRG00000013517.1, ENSPPRG00000013522.1, ENSPPRG00000013526.1)
  35. Panthera tigris altaica miRNA (ENSPTIG00000003456.1)
  36. Pan troglodytes (chimpanzee) microRNA ptr-mir-29b precursor (ptr-mir-29b-2)
  37. Pongo abelii (Sumatran orangutan) miRNA
  38. Pongo pygmaeus microRNA ppy-mir-29b precursor (ppy-mir-29b-2)
  39. Procavia capensis miRNA (ENSPCAG00000019197.1)
  40. Propithecus coquereli (Coquerel's sifaka) miRNA (ENSPCOG00000001941.1)
  41. Pteropus vampyrus miRNA (ENSPVAG00000026935.1)
  42. Rattus norvegicus (Norway rat) microRNA rno-mir-29b precursor (rno-mir-29b-2, rno-mir-29b-3)
  43. Rhinopithecus bieti (Black snub-nosed monkey) miRNA (ENSRBIG00000019951.1)
  44. Rhinopithecus roxellana miRNA (ENSRROG00000025511.1)
  45. Saguinus labiatus (red-chested mustached tamarin) microRNA sla-mir-29b precursor
  46. Saimiri boliviensis boliviensis (Bolivian squirrel monkey) miRNA (ENSSBOG00000016640.1)
  47. Tursiops truncatus (bottlenosed dolphin) microRNA 29b-2 (ENSTTRG00000022706.1, ENSTTRG00000023768.1)
  48. Vicugna pacos miRNA (ENSVPAG00000016729.1)
Publications