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hsa-mir-137: Interestingly, among the ncRNA-induced genes following Sin1 is MIR137HG (Table 1), a precursor of hsa-mir-137 and hsa-miR-2682, two highly expressed miRNAs of the CNS and especially the brain cortex [PMC9680243]. Because CKS1B copy gain and increased expression in hypoxia were KDM4A-dependent, we hypothesized that hsa-mir-23a/b and hsa-mir-137 would promote gain and increased expression for CKS1B [PMC4777823]. We then found downregulation of hsa-mir-137 after PMs exposure in RA-FLS, suggesting its role in the PMs-induced RA exacerbation [PMC7348867].
mRNA interactions
11 total
Genome locations
Gene Ontology annotations
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