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hsa-mir-574: hsa-mir-574 is an oncogenic miRNA that is upregulated in colorectal cancer liver metastasis and negatively regulates the metastasis associated in colon cancer [PMC5260001]. It is part of a miRNA signature that includes hsa-let-7i, hsa-miR-34a, hsa-miR-185, and hsa-miR-31, which are downregulated in colorectal cancer liver metastasis [PMC5511817]. In various cancer types, including hepatocellular carcinoma (HCC), Burkitt lymphoma (BL), and breast cancer (BC), hsa-mir-574 has been found to be associated with overall survival and prognosis [PMC7467934] [PMC8473752]. It has also been shown to have a positive regulation function on smooth muscle cell proliferation and blood vessel morphogenesis through EDN1 [PMC4222264]. Additionally, hsa-mir-574 has been identified as one of the top-ranked miRNAs associated with colorectal cancer liver metastasis [PMC5260001]. In HCC patients, it is part of a miRNA signature that includes other miRNAs such as hsa-miR-550a, hsa-miR-518b, and hsa-miR-512 that are significantly associated with prognosis [PMC7467934]. Furthermore, it has been found to be significantly expressed in tumor samples compared to normal samples in HCC patients [PMC7467934]. Overall, the evidence suggests that hsa-mir-574 plays an important role in various cancers and may have potential as a prognostic marker.
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