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hsa-mir-4649: Hsa-mir-4649 is a microRNA that has been identified as a potential biomarker for non-ischemic heart failure. Integrative bioinformatics analysis has shown that hsa-mir-4649, along with hsa-miR-1297, can target COX-2 and may be used as biomarkers for non-ischemic heart failure [PMC7419645]. Further investigation revealed a positive correlation between plasma COX-2 and plasma hsa-mir-4649 [PMC7419645]. Binary logistical regression analysis was used to evaluate the predictive powers of plasma PTGS2 (COX-2), hsa-mir-4649, and hsa-miR-1297 for heart failure [PMC7419645]. Hsa-mir-4649 was found to be significantly increased in the plasma of patients with non-ischemic heart failure compared to control subjects [PMC7419645]. Additionally, the expression of hsa-mir-4649 was associated with a worse outcome in patients with B-cell acute lymphoblastic leukemia (B-ALL) [PMC9624360]. Interestingly, hsa-mir-4649 polymorphisms were found to reside within the Drosha cleavage site and within the exon 1 of the AEBP1 host gene [PMC4299713]. Overall, these findings suggest that hsa-mir-4649 may play a role in non-ischemic heart failure and B-cell acute lymphoblastic leukemia.
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