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ssc-mir-15a: Ssc-mir-15a is a microRNA that has been identified in M pig, specifically in the 60/120, 120/150, 150/180, and 180/210 dpn comparisons [PMC4890935]. It is one of the nine common miRNAs found in these comparisons [PMC4890935]. Ssc-mir-15a has been found to potentially regulate genes in the neutrophil degranulation pathway and the TLR cascade pathway [PMC8851844]. It is also inhibited by SFN in porcine miRNAs [PMC9179638]. TargetScan predicts that ssc-mir-15a targets SMAD7 [PMC9179638]. Ssc-mir-15a is one of several miRNAs that are significantly regulated at 14 days post-infection, suggesting its involvement in the clearance of infection [PMC4759598]. It has also been implicated in the modulation of apoptosis and viral recognition signaling cascades along with ssc-miR-18a, ssc-miR-21, ssc-miR-29b, and hsa-miR-590-3p [PMC5909910]. These miRNAs are significantly up-regulated on day 3 after challenge but not regulated at other time points [PMC5909910]. Ssc-mir-15a has a specific forward primer for amplification during miRNA analysis [PMC4908419]. Additionally, circ_0000576 has been predicted to act as a sponge for ssc-mir-15a along with ssc-miR-98 and ssc-miR-885-3p to regulate muscle growth and development [PMC10099641].
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