mmu-mir-106a: The mmu-mir-106a cluster is a type of miRNA cluster that has been studied in various mouse tumors [PMC1794537]. In these tumors, approximately 70% showed increased expression levels of mmu-mir-106a [PMC1794537]. Synthetic RNA oligos were used to generate a calibration curve for mmu-mir-106a [PMC1794537]. Retroviral integrations were found upstream of the mmu-mir-106a cluster in some tumors, and these integrations were associated with increased expression levels of the mature miRNA [PMC1794537]. The retroviral integrations in this region affected the expression of the mir-106a cistron, as measured by qPCR [PMC1794537]. The mir-106a cistron is part of the primary transcripts containing the miRNA cluster [PMC1794537]. In addition to mmu-mir-106a, other miRNAs such as mmu-miR-20b and mmu-miR-19b-2 have been found to be upregulated in tumors with retroviral integration within the mir-106a-363 locus [PMC7290785]. The expression levels of mmu-mir-106a have been shown to be decreased in mice with diabetic peripheral neuropathy and it has been identified as a target for 12/15-lipoxygenase (12/15 LOX) [PMC8914318]. Overall, studies have demonstrated that retroviral insertions can induce overexpression of oncogenic miRNAs such as mmu-mir17 and mmu-mir 363, among others [PMC2257975].