mmu-mir-132: mmu-mir-132 is a microRNA that is co-transcribed with mmu-miR-212 and is involved in regulating its processing [PMC4780006]. Proteins that associate with the mmu-mir-132 loop and potentially regulate its processing have been isolated [PMC4780006]. The loop structure of mmu-mir-132 plays a role in recognizing protein factors, rather than directly influencing cleavage efficiency [PMC4780006]. The protein p72 is responsible for the stability of the primary transcript of mmu-mir-132 and may also affect its processing efficiency [PMC4780006]. Mutations in the loop of mmu-mir-132 have been generated to test their impact on processing [PMC4780006]. Mmu-mir-132 has been found to be downregulated in early-symptomatic α-synuclein (A30P)-transgenic mice, along with other microRNAs such as mmu-miR-10b, mmu-miR-10a, and mmu-miR-495 [PMC5116472]. Age-dependent decrease in abundance of mmu-mir-132 has been observed in mouse oocytes, particularly in response to oxidative stress [PMC6555462]. Mmu-mir-132 has also been found to be upregulated along with other miRNAs such as mmu-miR-212 and mmu-miR1298 during 21d-P6 development [PMC4499447]. Mmu-mir-132 is a brain-enriched miRNA that regulates circadian rhythm and neuronal morphogenesis [PMC3091680].

mmu-mir-212: Mmu-mir-212 is a microRNA that is highly upregulated in mouse periovulatory granulosa cells following luteinizing hormone (LH)/hCG induction [PMC4390370]. It has been found to post-transcriptionally regulate C-terminal-binding protein 1 [PMC4390370]. In a study of α-synuclein (A30P)-transgenic mice, mmu-mir-212 was one of five microRNAs found to be downregulated in early-symptomatic mice [PMC5116472]. In another study, mmu-mir-212 showed a fold change of 3.71 in upregulation during 21d-P6 [PMC4499447]. Taqman probes were used to quantify mmu-mir-212 expression, along with other miRNAs and mRNAs [PMC8580415] [PMC4280038]. The aim of one study was to identify protein factors that facilitate mmu-miR-132 processing over mmu-mir-212, as they are co-transcribed and related miRNAs [PMC4780006]. The miRCURY LNA microRNA detection probes were used to detect mmu-mir-212 expression [PMC6842347]. Mmu-mir-212 has been found to be significantly correlated with over 10,000 mRNA transcripts in the liver gene regulatory network [PMC3130556]. References: 1. PMC4390370 2. PMC8580415 3. PMC5116472 4. PMC4499447 5. PMC4280038 6. PMC4780006 7. PMC6842347 8. PMC3130556