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oar-mir-26a: Oar-mir-26a is a differentially expressed miRNA that has been studied in various contexts. It has been verified by q-PCR in a study that examined differentially expressed miRNAs in the infarcted area and infarct boundary area [PMC5611885]. The expression of oar-mir-26a was found to be upregulated in the infarct boundary area [PMC5611885]. Additionally, oar-mir-26a was found to be significantly differentially expressed between the unloading group and control group [PMC5611885]. Functional annotations and pathway enrichment analysis revealed that oar-mir-26a is involved in reentry into the mitotic cell cycle, leukocyte mediated immunity, gap junction channel activity, and several signaling pathways including Lysosome, Jak-STAT signaling pathway, and adrenergic signaling in cardiomyocytes [PMC5611885]. It has also been identified as one of the top 20 immune-related miRNAs in sheep [PMC7070426]. Furthermore, oar-mir-26a has been shown to have higher expression levels compared to other miRNAs such as oar-miR-10b and novel-miR-31 under certain conditions [PMC4401794] [PMC4440528]. It has also been used as a normalizer miRNA for gene expression analysis in sheep tissues due to its consistent amplification across samples [PMC5709059]. Additionally, it has been implicated as a target of LOC105611671 lncRNA for regulating FGF9 expression and promoting testicular steroidogenesis in Hu sheep Leydig cells [PMC9940382] [PMC9219891]. Oar-mir-26a along with Oar-miR-181a and Oar-miR-143 have shown higher levels of expression during the breeding season [PMC7992348].
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