SNORD26: SNORD26 is a C/D box small nucleolar RNA (snoRNA) that is located within the inside-out gene SNHG1 and is one of the eight C/D box snoRNAs hosted by SNHG1 [PMC4378963]. Dysfunction of SNORD26, along with SNORD44 and SNORD78, has been shown to result in severe morphological abnormalities and embryonic death [PMC10102602]. The intracellular level of SNHG1, which hosts SNORD26, can be repressed by p53 activation [PMC7154078]. The expression of SNORD26 has been found to be increased in chondrocytes isolated from osteoarthritis (OA) cartilage [PMC7326970]. Knockdown of SNORD26 in primary human articular chondrocytes (HACs) has been shown to alter the expression of chondrogenic, hypertrophic, and OA-related genes [PMC7326970]. Overexpression of SNORD26 in primary chondrocytes also leads to changes in gene expression related to chondrogenesis and OA [PMC7326970]. Additionally, differential expression of SNORD26 has been found to be predominantly OA-related [PMC7326970]. The expression level of SNORD26 has also been found to increase in osteoarthritis cartilage compared to non-OA cartilage [PMC9127141]. Mechanistic analysis suggests that both SNORD26 and another snoRNA called SNORD96A are involved in determining the chondrocyte phenotype [PMC8638817]. Overall, these findings highlight the importance of snoRNA such as SNORD26 in regulating gene expression and cellular processes related to cartilage development and osteoarthritis.