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ssc-mir-181c: Ssc-mir-181c is a microRNA that has been found to be down-regulated upon ZEN exposure, along with six other microRNAs, and up-regulated in the uterus but down-regulated in serum [PMC6722729] [PMC6598998]. It has been suggested that ssc-mir-181c, along with other members of the miR-181 family, plays a role in embryo implantation and placentation in pigs [PMC6598998]. Ssc-mir-181c has also been shown to decrease the translation level of CD163, a receptor involved in PRRSV infection, by binding to its mRNA [PMC9522899]. This binding inhibits PRRSV entry into porcine alveolar macrophages (PAMs) and suggests that ssc-mir-181c could be developed into therapeutics against PRRSV infection [PMC9522899]. Additionally, ssc-mir-181c has been found to have a higher expression level in blood monocytes compared to PAMs, indicating its potential role in suppressing PRRSV infection by targeting CD163 mRNA expression [PMC9522899]. Furthermore, ssc-mir-181c has been predicted to have binding sites on PPP1R10 and SLA-DRA genes [PMC3490867]. Overall, ssc-mir-181c is involved in various biological processes and may have potential implications for reproductive health and viral infections.
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Gene Ontology annotations
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