hsa-mir-186: Hsa-mir-186 is a human microRNA that is known to be upregulated in response to HIV-1 infection, targeting Dicer-1, HIV-EP2, and HRB, which are involved in various aspects of HIV-1 replication and pathogenesis [PMC9741442]. In addition to its role in HIV infection, hsa-mir-186 has also been implicated in adult T-cell leukemia/lymphoma (ATLL) [PMC8244200]. A primary analysis of microarray datasets revealed that hsa-mir-186 is differentially expressed in ATLL patients compared to normal individuals [PMC8244200]. This suggests that hsa-mir-186 may play a role in the development and progression of ATLL. Other microRNAs such as hsa-let-7a, hsa-let-7g, hsa-mir-181b, hsa-mir26b, hsa-mir30c, hsa-mir10a, hsa-mir30b, and haslet7f were also identified as differentially expressed in ATLL patients [PMC8244200]. These findings highlight the potential importance of microRNAs in the pathogenesis of ATLL and suggest that further investigation into the role of these microRNAs may provide insights into disease mechanisms and potential therapeutic targets.